Reaction of methyl esters of fluorinated β-keto acids with hydroxyl-containing nucleophiles
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When hydroxyl-containing nucleophiles add to fluorinatedβ-keto esters they add to the enol form of the β-keto ester.
An increase in the length of the fluoroalkyl substituent from HCF2 to n-C4F9, and also an increase in the size of the hydroxyl-containing nucleophile substituent, both lead to a decrease in the amount of the adduct for the fluorinatedβ-keto esters when they are reacted with hydroxyl-containing nucleophiles.
KeywordsMethyl Ester Adduct Methyl Ester Enol
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