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Synthesis and anticholinesterase activity of S-alkynyl diethyl thiophosphates containing hydrophobic or onium groups in the alkylthiol radical

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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusion

A study has been carried out of the anticholinesterase activity of S-alkynyl dialkyl thiophosphates containing hydrophobic or onium groups in the thioalkyl radical. It has been shown that interaction of the acetylenic bond with the corresponding region of the enzyme is not in accordance with the hydrophobic interaction of the thioalkyl radical. The presence of an acetylenic bond in the onium compounds results in a decrease in their inhibitory activity as compared with the analogous uncharged compounds.

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Literature cited

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Authors and Affiliations

  1. A. N. Nesmeyanov Institute of Heteroorganic Compounds, Academy of Sciences of the USSR, Moscow

    N. N. Godovikov, L. A. Vikhreva, E. K. Balashova, A. P. Brestkin, S. N. Moralev, V. I. Rozengart, O. E. Sherstobitov & M. I. Kabachnik

  2. I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Academy of Sciences of the USSR, Leningrad

    N. N. Godovikov, L. A. Vikhreva, E. K. Balashova, A. P. Brestkin, S. N. Moralev, V. I. Rozengart, O. E. Sherstobitov & M. I. Kabachnik

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  1. N. N. Godovikov
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  2. L. A. Vikhreva
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  3. E. K. Balashova
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  4. A. P. Brestkin
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  5. S. N. Moralev
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  6. V. I. Rozengart
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  7. O. E. Sherstobitov
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  8. M. I. Kabachnik
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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 8, pp. 1864–1868, August, 1986.

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Godovikov, N.N., Vikhreva, L.A., Balashova, E.K. et al. Synthesis and anticholinesterase activity of S-alkynyl diethyl thiophosphates containing hydrophobic or onium groups in the alkylthiol radical. Russ Chem Bull 35, 1694–1697 (1986). https://doi.org/10.1007/BF00954616

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  • DOI: https://doi.org/10.1007/BF00954616

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