Preparation of an allo-threonine derivative by the catalytic hydrogenation of ethyl α-acetylamino-β-ketobutyrate on modified catalysts

  • A. A. Vedenyanin
  • I. P. Murina
  • T. I. Kuznetsova
  • E. I. Klabunovskii
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Conclusions

The presence of a modifier and nature of the catalyst affect the steric selectivity of the hydrogenation of ethyl α-acetylamino-β-ketobutyrate. The hydrogenation of this ester in ethanol at 75°C and 10.0 MPa on Raney nickel modified by 5% aqueous RR-(+)-tartaric acid at pH 5.0 and 50°C gave the ethyl ester of N-acetyl-allo-threonine in 82% yield.

Keywords

Hydrogenation Ester Nickel Ethyl Ethyl Ester 

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Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • A. A. Vedenyanin
    • 1
  • I. P. Murina
    • 1
  • T. I. Kuznetsova
    • 1
  • E. I. Klabunovskii
    • 1
  1. 1.N. D. Zelinskii Institute of Organic ChemistryAcademy of Sciences of the USSRMoscow

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