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Formation of 5-S-cystamine-5,6-dihydrothymine in radiolysis of aqueous solutions of thymine and cystamine

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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    A method for synthesis of 5-S-cystamine-5,6-dihydrothymine was developed.

  2. 2.

    This compound is stable in neutral and acid solutions but rapidly decomposes according to a first-order reaction at pH 10–12. It was found that decomposition is due to acidbase dissociation of 5-S-cystamine-5,6-dihydrothymine (pK ∼ 11.1) and that the rate of decomposition increases with an increase in the pH of the solutions.

  3. 3.

    The products of cross-linking of these compounds, 5-S-cystamine-6-hydroxythymine and 5-S-cystamine-5,6-dihydrothymine, are formed in radiolysis of deaerated acid solutions containing thymine and cystamine.

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Authors and Affiliations

  1. B. P. Konstantinov Leningrad Institute of Nuclear Physics, Academy of Sciences of the USSR, Gatchina

    S. A. Grachev, E. V. Kropachev & G. I. Litvyakova

Authors
  1. S. A. Grachev
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  2. E. V. Kropachev
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  3. G. I. Litvyakova
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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 6, pp. 1270–1275, June, 1984.

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Grachev, S.A., Kropachev, E.V. & Litvyakova, G.I. Formation of 5-S-cystamine-5,6-dihydrothymine in radiolysis of aqueous solutions of thymine and cystamine. Russ Chem Bull 33, 1165–1170 (1984). https://doi.org/10.1007/BF00948980

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  • DOI: https://doi.org/10.1007/BF00948980

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