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Endothelin-like immunoreactivity in aqueous humor of patients with primary open-angle glaucoma and cataract

  • Walter Noske
  • Johannes Hensen
  • Michael Wiederholt
Clinical Investigation

Abstract

• Background: Experimental evidence suggests a role of endothelin-1 (ET) in the regulation of intraocular pressure (IOP). • Method: Therefore, inpatients undergoing cataract surgery, ET-like immunoreactivity (STIR) was measured by radioimmunoassay in pooled samples of aqueous humor of eyes with primary open-angle glaucoma (POAG) and normotensive eyes with cataract only. • Results: ETIR was significantly (P < 0.05) higher in patients with cataract and POAG (20.5 ± 1.8 pg/ml,n = 12; preoperative IOP 21.4 ± I.1 mmHg,n = 33) than in patients with cataract only (15.8 ± 1.6 pg/m1,n = 15; preoperative IOP 16.0 ± 0.6 mmHg,n = 77). • Conclusion: This finding may indicate a role of ET in POAG or ocular antihypertensive treatment, and its relevance should be further investigated.

Keywords

Public Health Glaucoma Experimental Evidence Cataract Intraocular Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • Walter Noske
    • 1
  • Johannes Hensen
    • 2
  • Michael Wiederholt
    • 3
  1. 1.Department of OphthalmologyBenjamin Franklin University Hospital, Free University of BerlinBerlinGermany
  2. 2.Department of Internal MedicineFriedrich-Alexander University Erlangen-NürnbergErlangenGermany
  3. 3.Department of Clinical PhysiologyBenjamin Franklin University Hospital, Free University of BerlinBerlinGermany

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