Endothelin-like immunoreactivity in aqueous humor of patients with primary open-angle glaucoma and cataract

  • Walter Noske
  • Johannes Hensen
  • Michael Wiederholt
Clinical Investigation


• Background: Experimental evidence suggests a role of endothelin-1 (ET) in the regulation of intraocular pressure (IOP). • Method: Therefore, inpatients undergoing cataract surgery, ET-like immunoreactivity (STIR) was measured by radioimmunoassay in pooled samples of aqueous humor of eyes with primary open-angle glaucoma (POAG) and normotensive eyes with cataract only. • Results: ETIR was significantly (P < 0.05) higher in patients with cataract and POAG (20.5 ± 1.8 pg/ml,n = 12; preoperative IOP 21.4 ± I.1 mmHg,n = 33) than in patients with cataract only (15.8 ± 1.6 pg/m1,n = 15; preoperative IOP 16.0 ± 0.6 mmHg,n = 77). • Conclusion: This finding may indicate a role of ET in POAG or ocular antihypertensive treatment, and its relevance should be further investigated.


Public Health Glaucoma Experimental Evidence Cataract Intraocular Pressure 


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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • Walter Noske
    • 1
  • Johannes Hensen
    • 2
  • Michael Wiederholt
    • 3
  1. 1.Department of OphthalmologyBenjamin Franklin University Hospital, Free University of BerlinBerlinGermany
  2. 2.Department of Internal MedicineFriedrich-Alexander University Erlangen-NürnbergErlangenGermany
  3. 3.Department of Clinical PhysiologyBenjamin Franklin University Hospital, Free University of BerlinBerlinGermany

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