Endothelin-like immunoreactivity in aqueous humor of patients with primary open-angle glaucoma and cataract
• Background: Experimental evidence suggests a role of endothelin-1 (ET) in the regulation of intraocular pressure (IOP). • Method: Therefore, inpatients undergoing cataract surgery, ET-like immunoreactivity (STIR) was measured by radioimmunoassay in pooled samples of aqueous humor of eyes with primary open-angle glaucoma (POAG) and normotensive eyes with cataract only. • Results: ETIR was significantly (P < 0.05) higher in patients with cataract and POAG (20.5 ± 1.8 pg/ml,n = 12; preoperative IOP 21.4 ± I.1 mmHg,n = 33) than in patients with cataract only (15.8 ± 1.6 pg/m1,n = 15; preoperative IOP 16.0 ± 0.6 mmHg,n = 77). • Conclusion: This finding may indicate a role of ET in POAG or ocular antihypertensive treatment, and its relevance should be further investigated.
KeywordsPublic Health Glaucoma Experimental Evidence Cataract Intraocular Pressure
- 2.Kaiser HJ, Hammer J, Wenk M, Lüscher T (1995) Endothelin-1 plasma levels in normal-tension glaucoma: abnormal response to postural changes. Graefe's Arch Clin Exp Ophthalmol 233:484–488Google Scholar