Synthesis of substituted hydroxypyrazines

Conclusions

A new method was developed for the synthesis of substituted hydroxypyrazine derivatives by reacting the hydrochlorides ofα-amino ketones with the acid chlorides of N-phthaloyl-α-amino acids in acetone in the presence of diethylaniline, and subsequent treatment of the intermediate N-(N′-phthaloyl-α′-aminoacyl)-α-amino ketones with aqueous sodium acetate solution at 100°.

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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 10, pp. 2417–2421, October, 1978.

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Zav'yalov, S.I., Zavozin, A.G. Synthesis of substituted hydroxypyrazines. Russ Chem Bull 27, 2151–2155 (1978). https://doi.org/10.1007/BF00946552

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Keywords

  • Sodium
  • Acetate
  • Chloride
  • Acetone
  • Ketone