Conclusions
The method of mathematical experiment planning was used to find the conditions for the reaction of acetylene with acetanilide, where the yield of 3-anilino-1-butyne reaches 35%, with a selectivity of ∼97%.
Literature cited
German Patent 877,757 (1953); C. A.,52, 9203 (1958).
M. F. Shostakovskii, A. S. Atavin, B. A. Trofimov, and E. P. Vyalykh, USSR Inventor's Certificate 216,741 (1968); Byull. Izobr., No. 15 (1968).
B. A. Trofimov, E. P. Vyalykh, and S. F. Malysheva, Zh. Org. Khim.,12, 2469 (1976).
M. R. Rubtsov, Ninth Mendeleev Convention on General and Applied Chemistry [in Russian], Nauka (1965), p. 44.
A. A. Shamshurin and M. Z. Krimer, Physicochemical Properties of Pesticides [in Russian], Khimiya (1976), pp. 44, 272.
K. E. Schulte and G. Riicqur, Progress in Drug Research, Vol. 14, Balee, Birkhauser Verlag (1970).
M. Miocque and J. M. Vierfeohd, Ann. Pharm. Franc.,31, 721 (1973).
Yu. P. Adler, E. V. Markova, and Yu. V. Granovskii, Experiment Planning When Searching for the Optimum Conditions [in Russian], Nauka (1971).
V. V. Nalimov and N. A. Chernova, Statistical Methods of Planning Extreme Experiments [in Russian], Nauka (1965).
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 10, pp. 2402–2405, October, 1978.
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Trofimov, B.A., Istomina, S.N., Malysheva, S.F. et al. Study of reaction of acetylene with anilides by the mathematical planning method. Russ Chem Bull 27, 2135–2138 (1978). https://doi.org/10.1007/BF00946546
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DOI: https://doi.org/10.1007/BF00946546