Investigation of naphthyridines
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2-Acetyl-10-aryl-1,2,3,4-tetrahydrobenzo[b]-1,6-naphthyridines were obtained by reaction of 4′-(2′)-R-2-aminobenzophenones with 1-acetyl-4-piperidone, and their pKa values were determined. It was found that they are oxidized by hydrogen peroxide to give the corresponding N-oxides in good yields. The N-oxides are converted to the 4-acetoxy derivatives by the action of acetic anhydride.
KeywordsHydrogen Acetic Hydrogen Peroxide Organic Chemistry Anhydride
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