Chemistry of Heterocyclic Compounds

, Volume 12, Issue 10, pp 1144–1146 | Cite as

Investigation of naphthyridines

VIII. Synthesis and properties of 2-acetyl-10-aryl-1,2,3,4-tetrahydrobenzo[b]-1,6-naphthyridines
  • V. A. Khaldeeva
  • M. E. Konshin


2-Acetyl-10-aryl-1,2,3,4-tetrahydrobenzo[b]-1,6-naphthyridines were obtained by reaction of 4′-(2′)-R-2-aminobenzophenones with 1-acetyl-4-piperidone, and their pKa values were determined. It was found that they are oxidized by hydrogen peroxide to give the corresponding N-oxides in good yields. The N-oxides are converted to the 4-acetoxy derivatives by the action of acetic anhydride.


Hydrogen Acetic Hydrogen Peroxide Organic Chemistry Anhydride 
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Literature cited

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Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • V. A. Khaldeeva
    • 1
  • M. E. Konshin
    • 1
  1. 1.Perm Pharmaceutical InstituteUSSR

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