Skip to main content
SpringerLink
Log in

Synthesis of peptides based onβ-(N1-uracilyl)-α-alanine

  • Published:
Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The synthesis of peptides which include a DL-β-(N1-uracilyl)-α-alanine (DL-willardiine) residue as an N-terminal or C-terminal group was investigated, dipeptides of DL-willardiine with glycine and L-tyrosine were obtained, and DL-willardiyl-DL-willardiine was synthesized; the latter is the simplest representative of the family of monotonic homopeptides which contain, as a repeating side substituent, a natural nucleic base capable of participation in intermolecular interactions of the complementary type.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature cited

  1. M. Yu. Lidak, R. A. Paégle, M, G. Plata, K. Ya. Pets, and Yu. P. Shvachkin, Khim. Geterotsikl. Soedin., 379 (1968).

  2. Yu. P. Shvachkin, Amino Acids of the Pyrimidine Series [in Russian], Moscow (1965), pp. 3–6, 29–40, and 47–50.

  3. R. A. Paégle, M. G. Plata, M. Yu. Lidak, S. A. Giller, and Yu. P. Shvachkin, in: Modern State of the Chemotherapy of Malignant Tumors [in Russian], Riga (1968), p. 103.

  4. M. Yu. Lidak, Ya. Ya. Shluke, and Yu. P. Shvachkin, Khim. Geterotsikl. Soedin., 955 (1968).

  5. Ya. Ya. Shluke, M. Yu. Lidak, S. A. Giller, and Yu. P. Shvachkin, in: Modern State of the Chemotherapy of Malignant Tumors [in Russian], Riga (1968), p. 124.

  6. R. Gmelin, Z. Physiol. Chem.,316, 164 (1959).

    Google Scholar 

  7. P. Hietala, Ann. Acad. Sci. Fenn.,A11, 100 (1960).

    Google Scholar 

  8. R. Gmelin, Acta Chem. Scand.,15, 1188 (1961).

    Google Scholar 

  9. F. Lambein and R. Van Parys, Biochem. Biophys, Res. Comm.,32, 474 (1968).

    Google Scholar 

  10. G. Shaw and J. H. Dewar, Proc. Chem. Soc., 216 (1961).

  11. J. H. Dewar and G. Shaw, J. Chem. Soc., 583 (1962).

  12. A. Kjaer, A. Knudsen, and P. O. Larsen, Acta Chem. Scand.,15, 1193 (1961).

    Google Scholar 

  13. A. P. Martinez and W. W. Lee, J. Org. Chem.,30, 317 (1965).

    Google Scholar 

  14. Yu. P. Shvachkin and M. T. Azarova, Zh. Obshch. Khim.,32, 3448 (1962).

    Google Scholar 

  15. M. Yu. Lidak, Ya. Ya. Shluke, S. E. Poritere, and Yu. P. Shvachkin, Khim. Geterotsikl. Soedin., 529 (1970).

Download references

Author information

Authors and Affiliations

  1. Institute of Organic Synthesis, Academy of Sciences of the Latvian SSR the Latvia, Riga

    M. Yu. Lidak, R. A. Paégle, V. É. Straume, D. É. Shnore & Yu. P. Shvachkin

  2. M. V. Lomonosov Moscow State University, USSR

    M. Yu. Lidak, R. A. Paégle, V. É. Straume, D. É. Shnore & Yu. P. Shvachkin

Authors
  1. M. Yu. Lidak
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. A. Paégle
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. É. Straume
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. É. Shnore
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yu. P. Shvachkin
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 404–408, March, 1971.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lidak, M.Y., Paégle, R.A., Straume, V.É. et al. Synthesis of peptides based onβ-(N1-uracilyl)-α-alanine. Chem Heterocycl Compd 7, 372–376 (1971). https://doi.org/10.1007/BF00944427

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00944427

Keywords

Search

Navigation