Abstract
The chlorine of 8-chloroquinoline undergoes a metathetical reaction with methylamine or ethylamine in aqueous solution under pressure in the presence of cuprous chloride, to give 8-methylaminoquinoline and 8-ethylaminoquinoline. The preparation of 8-aminoquinoline from 8-chloroauinoline is confirmed.
References
N. N. Vorozhtsov, Jr. and S. P. Mitsengendler, ZhOKh,6, 681, 1936.
S. Yoshida, J. Pharm. Soc. Japan.,67, 65, 1947; C. A.,45, 9543, 1951.
M. Yasuye and T. Yasukawa, J. Pharm. Soc. Japan.,66, 4, 1946; C. A., 45, 6204, 1951.
Heterocyclic Compounds, ed. R. Elderfield [Russian translation], IL, Moscow, 1955.
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Vorozhtsov, N.N., Skrebkova, N.I. Preparation of 8-alkylaminoquinolines from 8-chloroquinolines. Chem Heterocycl Compd 3, 115 (1967). https://doi.org/10.1007/BF00944283
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DOI: https://doi.org/10.1007/BF00944283