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Investigational New Drugs

, Volume 10, Issue 4, pp 299–301 | Cite as

Phase II trial of intravenous hexamethylmelamine in patients with advanced ovarian cancer

  • Mark D. Hauge
  • Harry J. Long
  • Lynn C. Hartmann
  • John H. Edmonson
  • Maurice J. Webb
  • John Su
Phase II Clinical Trials

Abstract

A Phase II trial of an intravenous preparation of Hexamethylmelamine was performed in ovarian cancer. Patients who had received prior Platinum based chemotherapy and had measurable disease were eligible. Among 15 evaluable patients, there were no objective responses. Two patients did show clinical and laboratory evidence of improvement. Toxicity was predominantly nausea and vomiting with minimal other toxicity. This intravenous form of Hexamethylmelamine has not shown meaningful activity in ovarian cancer patients who have failed prior platinum treatment.

Key words

hexamethylmelamine ovarian cancer chemotherapy ovarian cancer 

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References

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Copyright information

© Kluwer Academic Publishers 1992

Authors and Affiliations

  • Mark D. Hauge
    • 1
  • Harry J. Long
    • 2
  • Lynn C. Hartmann
    • 2
  • John H. Edmonson
    • 2
  • Maurice J. Webb
    • 3
  • John Su
    • 4
  1. 1.Section of Hematology and Medical OncologyMayo Clinic JacksonvilleJacksonvilleUSA
  2. 2.Division of Medical OncologyMayo Clinic and Mayo FoundationRochesterUSA
  3. 3.Section of Gynecologic SurgeryMayo Clinic and Mayo FoundationRochesterUSA
  4. 4.Section of EpidemiologyMayo Clinic and Mayo FoundationRochesterUSA

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