Central venous pressure and plasma arginine vasopressin in man during water immersion combined with changes in blood volume

  • P. Norsk
  • F. Bonde-Petersen
  • J. Warberg


To investigate the influence of central venous pressure (CVP) changes on plasma arginine vasopressin (pAVP), 8 normal male subjects were studied twice before, during and after immersion to the neck in water at 35.1‡±0.1‡ C (mean±SE) for 6 h. After 2 h of immersion, blood volume was either expanded (WIEXP) by intravenous infusion of 2.01 of isotonic saline during 2 h or reduced by loss of 0.51 of blood during 30 min (WIHEM). The two studies were randomised between subjects. WIEXP increased CVP, systolic arterial pressure (SAP), diuresis, natriuresis, kaliuresis and osmolar clearance compared to WIHEM while haematocrit, haemoglobin concentration and urine osmolality decreased. Heart rate, mean arterial (MAP) and diastolic arterial pressure, plasma osmolality, plasma sodium, plasma potassium and free water clearance did not differ significantly in the two studies. pAVP was significantly higher after 6 h in WIHEM than after 6 h in WIEXP (2.0±0.2 vs. 1.6±0.2 pg · ml−1, mean±SE;P<0.05). pAVP values were corrected for changes in plasma volume due to infusion in order properly to reflect AVP secretion. In conclusion, there was a weak, but significant, negative correlation between CVP and pAVP during the two studies, while during recovery from WIHEM and WIEXP decrements in SAP and MAP correlated significantly and strongly with increases in pAVP. It is therefore concluded that it is the arterial baroreceptors rather than the cardiopulmonary mechanoreceptors which are of importance in AVP regulation in man.

Key words

Arginine vasopressin Central venous pressure Central volume expansion Haemorrhage Water immersion 


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • P. Norsk
    • 1
  • F. Bonde-Petersen
    • 1
  • J. Warberg
    • 2
  1. 1.Laboratory for Human Physiology, August Krogh InstituteUniversity of CopenhagenCopenhagen
  2. 2.Institute of Medical Physiology C, Panum InstituteUniversity of CopenhagenCopenhagenDenmark

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