Abstract
The retinal toxicity of vancomycin in infusion solution used in vitrectomy and lensectomy was investigated in rabbit eyes by means of electroretinography and histologie study (light microscopy). Concentrations of 8μg/ ml, 16μg/ml, and 32μg/ml of vancomycin in balanced salt solution caused no abnormal ERG or histologic changes. However, ERG amplitude depression and abnormal histologie changes occurred when the concentration of 100μg/ml of vancomycin was used.
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Supported in part by U.S. Public Health Service grants EY07541 and EY02377 from the National Eye Institute, National Institutes of Health, Bethesda, MD.
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Borhani, H., Peyman, G.A. & Wafapoor, H. Use of vancomycin in vitrectomy infusion solution and evaluation of retinal toxicity. Int Ophthalmol 17, 85–88 (1993). https://doi.org/10.1007/BF00942780
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DOI: https://doi.org/10.1007/BF00942780