Zeitschrift für Parasitenkunde

, Volume 70, Issue 2, pp 211–218 | Cite as

Immunological unresponsiveness of lambs to infection withHaemonchus contortus

Modulation of responsiveness by exposure to soluble larval antigen
  • G. M. Monsell
  • A. H. Shubber
  • S. Lloyd
  • E. J. L. Soulsby
Original Investigations


The in vitro transformation of lymphocytes in the presence of antigen was used to assay the response of lambs to antigens ofHaemonchus contortus. Neither uninfected lambs nor lambs infected withH. contortus up to 9 weeks of age developed in vitro lymphocyte responsiveness to antigen. A slight and transient increase in reactivity was demonstrable in some of the infected lambs when these were reinfected withH. contortus at 26 weeks of age. This lack of responsiveness could be modulated through the exposure of lambs, early in neonatal life, to multiple parenteral injections of soluble third stage larval antigen ofH. contortus. Thus, antigen specific responses were apparent in the lymphocytes from 21-week-old lambs if these were injected with antigen when 2 to 17 weeks of age. In particular, marked antigen specific reactivity developed in 19- or 24-week-old lambs if such lambs were injected with antigen on five occasions over the first 6 weeks of life and subsequently infected withH. contortus when 7 weeks old. This responsiveness was enhanced when the lambs were reinfected withH. contortus at 26 weeks of age.


Transient Increase Specific Response Specific Reactivity Neonatal Life Parenteral Injection 
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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • G. M. Monsell
    • 1
  • A. H. Shubber
    • 1
  • S. Lloyd
    • 1
  • E. J. L. Soulsby
    • 1
  1. 1.Department of Clinical Veterinary MedicineUniversity of CambridgeCambridgeUK

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