Urological Research

, Volume 25, Supplement 1, pp S21–S23 | Cite as

Variable effects of iodinated contrast media on different rabbit arteries in vitro

  • D. Rauch
  • P. Drescher
  • J. M. Knes
  • P. O. Madsen
Original Paper


Vasoconstriction caused by iodinated contrast media (CM) has been considered specific for the renal artery only. We examined the vascular effect of CM in rabbit carotid, aorta, renal, iliac, mesenteric and celiac arteries and found that other arteries also respond with a contraction to CM. Isolated arterial rings were exposed to diatrizoate (high osmolar CM), iohexol (low osmolar CM) or glucose solution, and the isometric contraction response was expressed as percentage of an initial KCl control contraction. Diatrizoate evoked contractions of 82% (carotid), 63% (aorta), 30% (renal), 24% (iliac), 28% (mesenteric) and 18% (celiac), respectively. Iohexol caused contractions of 31% (carotid), 24% (aorta), 15% (renal) and 14% (iliac), whereas the mesenteric and celiac arteries were relaxed by iohexol. A high osmolar glucose solution elicited contractions of 78%, 77%,11%, 27%, 3% and 5%, respectively, in the arteries. CM have contraction potency in arterial vasculature other than the renal artery.

Key words

Iodinated contrast media Diatrizoate Iohexol Isolated arteries Organ bath Vasoconstriction 


  1. 1.
    Caldicott WJH, Hollenberg NK, Abrams HS (1970) Characteristics of response of renal vascular bed to contrast media. Invest Radiol 5:539PubMedGoogle Scholar
  2. 2.
    Drescher P (1995) Ca2+ and cyclic adenosine monophosphate involvement in radiographic contrast medium induced renal vasoconstriction. J Vase Interv Radiol 6:813Google Scholar
  3. 3.
    Eckert RE, Schreier U, Drescher P, Madsen PO, Derouet H, Becht E, Steffens J, Ziegler M (1995) Regulation of prostatic smooth muscle contractility by intracellular second messengers: Implications for the conservative treatment of benign prostatic hyperplasia. Urol Int 54:6PubMedGoogle Scholar
  4. 4.
    Gomi N (1992) Vasoconstriction by angiographic contrast media in isolated canine arteries. Br J Radiol 65:961PubMedGoogle Scholar
  5. 5.
    Heyman SN, Brezis M, Epstein FH, Spokes K, Silva P, Rosen S (1991) Early renal medullary hypoxic injury from radiocontrast and indomethacin. Kidney Int 40:632PubMedGoogle Scholar
  6. 6.
    Karstoft J, Bååth L, Jansen I, Edvinsson L (1995) Vasoconstriction of isolated arteries induced by angiographic contrast media. Acta Radiologica 36:312PubMedGoogle Scholar
  7. 7.
    Katzberg RW, Schulman G, Meggs LG, Caldicott WJH, Damiano MM, Hollenberg NK (1983) Mechanism of the renal response to contrast medium in dogs. Decrease in renal function due to hypertonicity. Invest Radiol 18:74PubMedGoogle Scholar
  8. 8.
    Lardani H, Rinaldi G, Cingolani H (1982) Effects of angiographic contrast medium on isolated canine coronary arteries. Am J Cardiol 50:869PubMedGoogle Scholar
  9. 9.
    Moore RD, Steinberg EP, Powe NR, Brinker JA, Fishman EK, Graziano S, Gopalan R (1992) Nephrotoxicity of high osmolality versus low osmolality contrast media: A randomized clinical trial. Radiology 182:649PubMedGoogle Scholar
  10. 10.
    Rudnick MR, Goldfarb S, Wexler L, Ludbrook PA, Murphy MJ, Halpern EF, Hill JA, Winniford M, Cohen MB, Van Fossen DB (1995) Nephrotoxicity of ionic and nonionic contrast media in 1196 patients: A randomized trial. Kidney Int 47:254PubMedGoogle Scholar
  11. 11.
    Schmidek HH, Moreira D, Harder DR (1983) Diatrizoate meglumine-induced dilation of rat basilar artery: An in vitro study. Neurosurgery 12:137PubMedGoogle Scholar
  12. 12.
    Schneider KM, Rand MJ (1988) Vasodilation and vasoconstriction in the rabbit isolated aorta effects of ioxilan, iohexol and diatrizoate. Invest Radiol 23 (Suppl 1):S150PubMedGoogle Scholar
  13. 13.
    Talner LB, Davidson AJ (1968) Renal hemodynamic effects of contrast media. Invest Radiol 3:310PubMedGoogle Scholar
  14. 14.
    Yamashita K, Hayakawa K, Masato T, Konishi J (1988) Cardiovascular responses following the intracarotid injections of ionic and nonionic contrast media compared with various mannitol solutions. Correlation with osmolality. Invest Radiol 23:680PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • D. Rauch
    • 1
  • P. Drescher
    • 2
  • J. M. Knes
    • 1
  • P. O. Madsen
    • 1
  1. 1.Department of Surgery, University of WisconsinSchool of Medicine and VA Medical CenterMadisonUSA
  2. 2.Department of RadiologyMedical College of WisconsinMilwaukeeUSA

Personalised recommendations