Urological Research

, Volume 25, Supplement 1, pp S21–S23 | Cite as

Variable effects of iodinated contrast media on different rabbit arteries in vitro

  • D. Rauch
  • P. Drescher
  • J. M. Knes
  • P. O. Madsen
Original Paper

Abstract

Vasoconstriction caused by iodinated contrast media (CM) has been considered specific for the renal artery only. We examined the vascular effect of CM in rabbit carotid, aorta, renal, iliac, mesenteric and celiac arteries and found that other arteries also respond with a contraction to CM. Isolated arterial rings were exposed to diatrizoate (high osmolar CM), iohexol (low osmolar CM) or glucose solution, and the isometric contraction response was expressed as percentage of an initial KCl control contraction. Diatrizoate evoked contractions of 82% (carotid), 63% (aorta), 30% (renal), 24% (iliac), 28% (mesenteric) and 18% (celiac), respectively. Iohexol caused contractions of 31% (carotid), 24% (aorta), 15% (renal) and 14% (iliac), whereas the mesenteric and celiac arteries were relaxed by iohexol. A high osmolar glucose solution elicited contractions of 78%, 77%,11%, 27%, 3% and 5%, respectively, in the arteries. CM have contraction potency in arterial vasculature other than the renal artery.

Key words

Iodinated contrast media Diatrizoate Iohexol Isolated arteries Organ bath Vasoconstriction 

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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • D. Rauch
    • 1
  • P. Drescher
    • 2
  • J. M. Knes
    • 1
  • P. O. Madsen
    • 1
  1. 1.Department of Surgery, University of WisconsinSchool of Medicine and VA Medical CenterMadisonUSA
  2. 2.Department of RadiologyMedical College of WisconsinMilwaukeeUSA

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