Abstract
• Background: Fibrous histiocytomas of the corneoscleral limbus are rare tumors. We present an additional case and review the treatment approaches in the literature. So far, only light and electron microscopic studies have been performed. We used immunohistochemical stains to further characterize the cellular composition. • Methods: The excised lesion was routinely fixed and processed for light microscopy and immunohistochemical studies. For comparison, three dermal fibrous histiocytomas were also examined and processed similarly. • Results: The corneolimbal tumor was mainly composed of fibroblasts and histiocytes with a large amount of interstitial collagen, arranged in a storiform pattern. Immunohistochemical stains were positive for histiocytes, fibroblasts, and a marker for mesenchymal cells. The staining pattern of the dermal lesions was similar. • Conclusion: Fibrous histiocytomas of the corneolimbal region are morphologically benign, slowly growing and infiltrative tumors. Complete resection, especially of the deep margin, is suggested. The immunohistochemical staining pattern is similar to that of dermal fibrous histiocytomas, which behave in a benign manner.
Similar content being viewed by others
References
Albert DM, Smith RS (1968) Fibrous xanthomas of the conjunctiva. Arch Ophthalmol 80:474–479
Balestrazzi E, Ventura T, Delle Noci N, Blasi MA, Spadea L, Coletti G (1991) Malignant conjunctival epibulbar fibrous histiocytoma with orbital invasion. Eur J Ophthalmol 1: 23–27
Delgado-Partida P, Rodriguez-Trujillo F (1972) Fibrosarcoma (malignant fibroxanthoma) involving conjunctiva and ciliary body. Am J Ophthalmol 74:479–485
Faludi JE, Kenyon K, Green WR (1975) Fibrous histiocytoma of the corneoscleral limbus. Am J Ophthalmol 80: 619–624
Font RL, Hidayat AA (1982) Fibrous histiocytoma of the orbit. A clinicopathologic study of 150 cases. Hum Pathol 13: 199–209
Fu Y-S, Gabbiani G, Kaye GI, Lattes R (1975) Malignant soft tissue tumors of probable histiocytic origin: general considerations and electron micro scopic and tissue culture studies. Cancer 35:176–198
Iwamoto T, Jacobiec FA, Darrell RW (1981) Fibrous histiocytoma of the corneoslceral limbus. The ultrastructure of a distinctive inclusion. Ophthalmology 88: 1260–1268
Jacobiec FA (1974) Fibrous histiocytoma of the corneoscleral limbus. Am J Ophthalmol 78:700–706
Klaus SN, Winkelmann RK (1966) The enzyme histochemistry of nodular subepidermal fibrosis. Br J Dermatol 78:398–402
Lahoud S, Brownstein S, Laflamme MY (1988) Fibrous histiocytoma of the corneoscleral limbus and conjunctiva. Am J Ophthalmol 106:579–583
Leong ASY (1993) Applied immunohistochemistry for the surgical pathologist. Arnold, London
Lever WF, Schaumburg-Lever G (1990) Histopathology of the skin, 7th edn. Lippincott, Philadelphia, pp 660–664
Litricin O (1983) Fibrous histiocytoma of the corneosclera. Arch Ophthalmol 101:426–428
Marback RL, Kincaid MC, Green WR, Iliff WJ (1982) Fibrous histiocytoma of the lacrimal sac. Am J Ophthalmol 93: 511–517
Margo CE, Horton MB (1989) Malignant fibrous histiocytoma of the conjunctiva with metastasis. Am J Ophthalmol 107:433–434
Moschella SL, Hurley HJ (1992) Dermatology, 3rd edn. Saunders, Philadelphia, p 1767
Notes JM, Kantelip B, Souedan M, Bacin F (1989) Fibrous histiocytoma of the conjunctiva. Ophthalmologica 199:47–49
Péer J, Levinger S, Ilsar M, Climenhaga H, Okon E (1990) Malignant fibrous histiocytoma of the conjunctiva. Br J Ophthalmol 74:624–628
Péer J, Levinger S, Chirambo M, Ron N, Okon E (1991) Malignant fibrous histiocytoma of the skin and the conjunctiva in xeroderma pigmentosa. Arch Pathol Lab Med 115: 910–914
Roth AM (1993) Malignant fibrous histiocytoma of the ocular adnexa. Metab Pediatr Syst Ophthalmol 16: 5–8
Saman K, Testinsky P, Hejda V (1979) Histiocytoma of the corneal limbus. Cesk Oftalmol 35:89–92
Spencer WH (1985) Sclera. In: Spencer WH Ophthalmic pathology: an atlas and textbook, 3rd edn. Saunders, Philadelphia, p 420
Urdiales-Viedma M, Moreno-Prieto M, Martos-Padilla S (1983) Pleomorphic fibrous histiocytoma of the corneoscleral limbus. Am J Ophthalmol 95:560–561
Wedemeyer LL, Fuerst DJ, Perlman AR, McDonnell J, Rao NA (1993) Fibrous histiocytoid leprosy of the cornea. Cornea 12:532–536
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Mietz, H., Severin, M., Arnold, G. et al. Management of fibrous histiocytoma of the corneoscleral limbus: Report of a case and review of the literature. Graefe's Arch Clin Exp Ophthalmol 235, 87–91 (1997). https://doi.org/10.1007/BF00941735
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00941735