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Journal of Neurology

, Volume 242, Supplement 1, pp S57–S60 | Cite as

Inflammation and axonal regeneration

  • P. M. Richardson
  • X. Lu
Article

Abstract

Inflammatory cells and their products contribute to neuronal survival and axonal regeneration after injury. Following sciatic nerve transection in rats, macrophages accumulate in the corresponding dorsal root ganglion, potentially supplying neurotrophic support to nerve cell bodies, and enhancing axonal regeneration. Growth factors characterized for their functions in the haematopoietic and immune systems also act on neurons and vice versa, by sharing common subunits among receptors for cytokines and neurotrophic factors.

Keywords

Public Health Growth Factor Immune System Inflammatory Cell Cell Body 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Baichwal RR, Bigbee JW and DeVries GH (1988) Macrophage-mediated myelin-related mitogenic factor for cultured Schwann cells. Proc Natl Acad Sci USA 85: 1701–1705Google Scholar
  2. 2.
    Bandtlow CE, Meyer M, Lindholm D, Spranger M, Heumann R and Thoenen H (1990) Regional and cellular codistribution of interleukin 1 beta and nerve growth factor mRNA in the adult rat brain: possible relationship to the regulation of nerve growth factor synthesis. J Cell Biol 111: 1701–1711Google Scholar
  3. 3.
    Barna BP, Estes ML, Jacobs BS, Hudson S and Ransohoff RM (1990) Human astrocytes proliferate in response to tumor necrosis factor alpha. J Neuroimmunol 30: 239–243Google Scholar
  4. 4.
    Barron KD, Marciano FF, Amundson R, Mankes R (1990) Perineuronal glial responses after axotomy of central and peripheral axons. A comparison. Brain Res 523: 219–229Google Scholar
  5. 5.
    Bazan JF (1991) Neuropoetic cytokines in the hematopoietic fold. Neuron 7: 197–208Google Scholar
  6. 6.
    Beuche W and Friede RL (1984) The role of non-resident cells in Wallerian degeneration. J Neurocytol 13: 767–796Google Scholar
  7. 7.
    Bisby MA and Chen S (1990) Delayed Wallerian degeneration in sciatic nerves of C57BL/Ola mice is associated with impaired regeneration of sensory axons. Brain Res 530: 117–120Google Scholar
  8. 8.
    Brown MC, Perry VH, Lunn ER, Cordon S and Heumann R (1991) Macrophage dependence of peripheral sensory nerve regeneration: possible involvement of nerve growth factor. Neuron 6: 359–370Google Scholar
  9. 9.
    Esiri MM and Reading MC (1989) Macrophages, lymphocytes and major histocompatibility complex (HLA) class II antigens in adult human sensory and sympathetic ganglia. J Neuroimmunol 23: 187–193Google Scholar
  10. 10.
    Freidin M, Bennett MVL and Kessler JA (1992) Cultured sympathetic neurons synthesize and release the cytokine interleukin 1 beta. Proc Natl Acad Sci USA 89: 10440–10443Google Scholar
  11. 11.
    Gearing DP, Thut CJ, VandenBos T et al (1991) Leukemia inhibitory factor receptor is structurally related to the Il6 signal transducer, gp130. Eur Mol Biol Jour 10: 2839–2848Google Scholar
  12. 12.
    Gehrmann J, Monaco S and Kreutzberg GW (1991) Spinal cord microglial cells and DRG satellite cells rapidly respond to transection of the rat sciatic nerve. Restor Neurol Neurosci 2: 181–198Google Scholar
  13. 13.
    Giulian D and Robertson C (1990) Inhibition of mononuclear phagocytes reduces ischemic injury in the spinal cord. Ann Neurol 27: 33–42Google Scholar
  14. 14.
    Glass JD, Brushart TM, George EB and Griffin JW (1993) Prolonged survival of transected nerve fibres in C57BL/Ola mice is an intrinsic characteristic of the axon. J Neurocytol 22: 311–321Google Scholar
  15. 15.
    Hao C, Guilbert LJ and Fedoroff S (1990) Production of colony-stimulating factor-1 (CSF-1) by mouse astroglia in vitro. J Neurosci Res 27: 314–323Google Scholar
  16. 16.
    Hattori A, Tanaka E, Murase K et al (1993) Tumor necrosis factor stimulates the synthesis and secretion of biologically active nerve growth factor in non-neuronal cells. J Biol Chem 268: 2577–2582Google Scholar
  17. 17.
    Henderson JT, Seniuk N, Richarson PM, Tatton W and Roder JC (1993) Transplantation of CNTF secreting cells and transgenic over-expression of CNTF in murine CNS and PNS. Soc Neurosci Abstr 19: 255Google Scholar
  18. 18.
    Heumann R, Lindholm D, Bandtlow C et al (1987) Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: role of macrophages. Proc Natl Acad Sci USA 84: 8735–8739Google Scholar
  19. 19.
    Ip NY, Nye SH, Boulton TG et al (1992) CNTF and LIF act on neuronal cells via shared signalling pathways that involve the IL-6 signal transducing receptor component gp130. Cell 69: 1121–1132Google Scholar
  20. 20.
    Ip NY, McClain J, Barrezueta NX et al (1993) The alpha component of the CNTF receptor is required for signalling and defines potential CNTF targets in the adult and during development. Neuron 10: 89–102Google Scholar
  21. 21.
    Lee SC, Liu W, Roth P, Dickson DW, Berman JW and Brosnan CF (1993) Macrophage colony-stimulating factor in human fetal astrocytes and microglia. J Immunol 150: 594–604Google Scholar
  22. 22.
    Lee SC, Liu W, Roth P, Dickson DW, Berman JW and Brosnan CF (1993) Cytokine production by by human fetal microglia and astrocytes. J Immunol 150: 2659–2667Google Scholar
  23. 23.
    Lindholm D, Heumann R, Hengerer B, Thoenen H (1988) Interleukin 1 increases stability and transcription of mRNA encoding nerve growth factor in cultured rat fibroblasts. J Biol Chem 263: 16348–16351Google Scholar
  24. 24.
    Lindholm D, Hengerer B, Zafra F and Thoenen H (1990) Transforming growth factor-beta 1 stimulates expression of nerve growth factor in the rat CNS. NeuroReport 1: 9–12Google Scholar
  25. 25.
    Lu X and Richardson PM (1991) Inflammation near the nerve cell body enhances axonal regeneration. J Neurosci 11: 972–978Google Scholar
  26. 26.
    Lu X and Richarson PM (1993) Responses of macrophages in rat dorsal root ganglia following peripheral nerve injury. J Neurocytol 22: 334–341Google Scholar
  27. 27.
    Perry VH, Brown MC and Gordon S (1987) The macrophage response to central and peripheral nerve injury. J Exp Med 165: 1218–1223Google Scholar
  28. 28.
    Perry VH, Brown MC, Lunn ER, Tree P and Gordon S (1990) Evidence that very slow Wallerian degeneration in C57BL/Ola mice is an intrinsic property of the peripheral nerve. Europ J Neurosci 2: 802–808Google Scholar
  29. 29.
    Rao MS, Tyrrell S, Landis SC and Patterson PH (1992) Effects of ciliary neurotrophic factor (CNTF) and depolarization on neuropeptide expression in cultured sympathetic neurons. Dev Biol 150: 281–293Google Scholar
  30. 30.
    Rao M, Sun Y, Escary J et al (1993) Leukemia inhibitory factor mediates an injury response but not a target-directed developmental transmitter switch in sympathetic neurons. Soc Neurosci Abstr 19: 664Google Scholar
  31. 31.
    Rogister B, Deiree P, Leprince P et al (1993) Transforming growth factor beta as a neuronoglial signal during peripheral nervous system response to injury. J Neurosci Res 34: 32–43Google Scholar
  32. 32.
    Satoh T, Nakamura S, Taga T et al (1988) Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6. Mol Cell Biol 8: 3546–3549Google Scholar
  33. 33.
    Selmaj KW, Farooq M, Norton WT, Raine CS and Brosnan CF (1990) Proliferation of astrocytes in vitro in response to cytokines. J Immunol 144: 129–135Google Scholar
  34. 34.
    Shadiack AM, Hart RP, Carlson CD and Jonakait GM (1993) Interleukin-1 induces substance P in sympathetic ganglia through the induction of leukemia inhibitory factor (LIF). J Neurosci 13: 2601–2609Google Scholar
  35. 35.
    Smith ML and Adrian EK (1972) On the presence of mononuclear leucocytes in dorsal root ganglia following transection of the sciatic nerve. Anat Rec 172: 581–588Google Scholar
  36. 36.
    Spranger M, Lindholm D, Bandtlow C et al (1989) Regulation of nerve growth factor (NGF) synthesis in the rat central nervous system: comparison between the effects of interleukin-1 and various growth factors in astrocyte cultures and in vivo. Europ J Neurosci 2: 69–76Google Scholar
  37. 37.
    Stahl N, Davis S, Wong V et al (1993) Cross-linking identifies leukemia inhibitory factor-binding protein as a ciliary neurotrophic factor receptor component. J Biol Chem 268: 7628–7631Google Scholar
  38. 38.
    Stewart CL, Kaspar P, Brunet LJ et al (1992) Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature 359: 78–79Google Scholar
  39. 39.
    Stoll G, Griffin JW, Li CY and Trapp BD (1989) Wallerian degeneration in the peripheral nervous system: participation of both Schwann cells and macrophages in myelin degradation. J Neurocytol 18: 671–683Google Scholar
  40. 40.
    Svensson M and Aldskogius H (1993) Regeneration of hypoglossal nerve axons following blockade of the axotomy-induced microglial cell reaction in the rat. Europ J Neurosci 5: 85–94Google Scholar
  41. 41.
    Thanos S, Mey J and Wild M (1993) Treatment of the adult retina with microglia-suppressing factors retards axotomy-induced neuronal degradation and enhances axonal regeneration in vivo and in vitro. J Neurosci 13: 455–466Google Scholar
  42. 42.
    Thomas PK (1974) Nerve injury. In: Eds. R. Bellairs, EG Gray. Essays on the Nervous System. Oxford: Clarendon 1974 pp 44–70Google Scholar
  43. 43.
    Yamamori T, Fukada K, Aebersold R, Korsching S, Farm M-J and Patterson PH (1989) The cholinergic neuronal differentiation factor from heart cells is identical to leukemia inhibitory factor. Science 246: 1412–1416Google Scholar
  44. 44.
    Yong VW, Moumdjian R, Yong FP et al (1991) Gamma-interferon promotes proliferation of adult human astrocytes in vitro and reactive gliosis in the adult mouse brain in vivo. Proc Natl Acad Sci USA 88: 7016–7020Google Scholar
  45. 45.
    Yoshida K and Gage FH (1992) Cooperative regulation of nerve growth factor synthesis and secretion in fibroblasts and astrocytes by fibroblast growth factor and other cytokines. Brain Res 569: 14–25Google Scholar

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • P. M. Richardson
    • 1
  • X. Lu
    • 1
  1. 1.Division of NeurosurgeryMontreal General Hospital and McGill UniversityMontrealCanada

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