Journal of Neurology

, Volume 242, Supplement 1, pp S57–S60 | Cite as

Inflammation and axonal regeneration

  • P. M. Richardson
  • X. Lu


Inflammatory cells and their products contribute to neuronal survival and axonal regeneration after injury. Following sciatic nerve transection in rats, macrophages accumulate in the corresponding dorsal root ganglion, potentially supplying neurotrophic support to nerve cell bodies, and enhancing axonal regeneration. Growth factors characterized for their functions in the haematopoietic and immune systems also act on neurons and vice versa, by sharing common subunits among receptors for cytokines and neurotrophic factors.


Public Health Growth Factor Immune System Inflammatory Cell Cell Body 
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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • P. M. Richardson
    • 1
  • X. Lu
    • 1
  1. 1.Division of NeurosurgeryMontreal General Hospital and McGill UniversityMontrealCanada

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