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Synthesen von Heterocyclen, 122. Mitt.: Über die Reaktion des Perimidons mit aktiven Malonestern

Syntheses of heterocycles, CXXII: Reaction of perimidone with reactive malonates

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Zusammenfassung

Perimidon (1) reagiert mit monosubstit. Malonsäure-trichlorphenylestern (2) bei 250° zu 9-Hydroxy-5,7-dioxo-4,5-dihydro-7H-pyrido[1,2,3-cd]perimidinen (3), die durch saure Hydrolyse zu 10-Amino-4-hydroxy-benzo[h]carbostyrilen (4) gespalten werden.

Abstract

Perimidone (1) reacts with monosubstituted 2.4.6-trichlorophenyl malonates at 250° to 9-hydroxy-5.7-dioxo-4.5-dihydro-7H-pyrido[1.2.3-cd]perimidines (3), which are cleaved by acid yielding 10-amino-4-hydroxy-benzo[h]quinolin-2-ones (4).

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  1. Institut für Organische und Pharmazeutische Chemie der Universität Graz, Graz, Österreich

    Th. Kappe, E. Ziegler & M. Ali A. Chirazi

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  1. Th. Kappe
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  2. E. Ziegler
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  3. M. Ali A. Chirazi
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Kappe, T., Ziegler, E. & Chirazi, M.A.A. Synthesen von Heterocyclen, 122. Mitt.: Über die Reaktion des Perimidons mit aktiven Malonestern. Monatshefte für Chemie 100, 142–145 (1969). https://doi.org/10.1007/BF00938249

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  • DOI: https://doi.org/10.1007/BF00938249

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