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Vanadium derivatives act as growth factor — mimetic compounds upon differentiation and proliferation of osteoblast-like UMR106 cells

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Abstract

The effect of different vanadium compounds on proliferation and differentiation was examined in osteoblast-like UMR106 cells. Vanadate increased the cell growth in a biphasic manner, the higher doses inhibiting cell progression. Vanadyl stimulated cell proliferation in a dose-responsive manner. Similar to vanadate, pervanadate increased osteoblast-like cell proliferation in a biphasic manner but no inhibition of growth was observed. Vanadyl and pervanadate were stronger stimulators of cell growth than vanadate. Only vanadate was able to regulate the cell differentiation as measured by cell alkaline phosphatase activity. These results suggest that vanadium derivatives behave like growth factors on osteoblast-like cells and are potential pharmacological tools in the control of cell growth.

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Authors and Affiliations

  1. Cátedra de Bioquímica Patológica, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, (1900), La Plata, Argentina

    Ana M. Cortizo & Susana B. Etcheverry

  2. Programa QUINOR, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, (1900), La Plata, Argentina

    Susana B. Etcheverry

Authors
  1. Ana M. Cortizo
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  2. Susana B. Etcheverry
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Cortizo, A.M., Etcheverry, S.B. Vanadium derivatives act as growth factor — mimetic compounds upon differentiation and proliferation of osteoblast-like UMR106 cells. Mol Cell Biochem 145, 97–102 (1995). https://doi.org/10.1007/BF00935481

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  • DOI: https://doi.org/10.1007/BF00935481

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