Archives of Gynecology and Obstetrics

, Volume 246, Issue 4, pp 223–226 | Cite as

Tumor necrosis factor and pregnancy - a contribution to the immunology of reproduction

  • H. -J. Voigt
  • L. Steib


Serum levels of the cytokine TNF (tumor necrosis factor) were determined in pregnant women during the first trimester and compared with levels in a control group of non-pregnant healthy women. A new immunoradiometric assay (IRMA) was used. In pregnant women we found a very low mean value of 2.5 pg/ml. The value was significantly higher 16.2 pg/ml in the non-pregnant group. This finding suggests supression of macrophage activity which could favour the fetal allograft.

Key words

Tumor necrosis factor Immunology Early pregnancy 


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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • H. -J. Voigt
    • 1
  • L. Steib
    • 1
  1. 1.Clinic for Gynecology and ObstetricsUniversity of ErlangenFRG

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