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The effects of selective immunosuppression on resistance toMesocestoides corti in strains of mice showing high and low initial susceptibility

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Abstract

Previous work has shown that C57BL/6 mice had the lowest initial susceptibility toMesocestoides corti of six strains of mice examined. Parasite burdens in this strain and in CBA/H mice, a strain showing a higher initial susceptibility toM. corti, were compared following selective immunosuppressive treatments. Irradiation, splenectomy and the administration of cyclophosphamide and methyl prednisolone all resulted in higher parasite burdens in C57BL/6 mice. In contrast these treatments had a minimal effect on parasite burdens in CBA/H mice. In the light of these results the role of antibody in controlling parasite proliferation is discussed.

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  1. Division of Veterinary Biology, School of Veterinary Studies, Murdoch University, 6150, Murdoch, Western Australia

    T. R. White, R. C. A. Thompson & W. J. Penhale

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  1. T. R. White
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  2. R. C. A. Thompson
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  3. W. J. Penhale
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White, T.R., Thompson, R.C.A. & Penhale, W.J. The effects of selective immunosuppression on resistance toMesocestoides corti in strains of mice showing high and low initial susceptibility. Z. Parasitenkd. 69, 91–104 (1983). https://doi.org/10.1007/BF00934013

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  • DOI: https://doi.org/10.1007/BF00934013

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