Schistosoma mansoni infection of Syrian golden hamsters: The host humoral immune response in relation to the adult worm burdens after primary infection
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Seven-week-old female Syrian golden hamsters (Mesocricetus auratus) showed different degrees of susceptibility toSchistosoma mansoni, as assessed by the percentage of cercariae recovered as adult worms 6 weeks after infection. Plasma of the low (A), medium (B) and high (C) susceptibility groups were tested immunochemically. No differences were observed in the concentrations of albumin, α1-, α2-, ;β- and γ-globulins as measured by cellulose acetate electrophoresis. However, a significantly higher percentage of animals in groups A and B than in group C had anS. mansoni specific “beforked” IgG precipitin band and specific antibodies against a worm tegumental antigen preparation (AWT).
Conversely, more animals in group C made antibodies against a “denuded” worm-body antigen preparation (AWB) than in groups A and B. However, by using the enzyme-linked immunosorbent assay, no significant differences in antibody titres against AWT, AWB and a total worm antigen (AVA) were observed in the animals in groups A, B and C.
Upon consideration of the immunochemical data in relation to the distribution pattern of susceptibility to infection, we propose that the intensity ofS. mansoni infection in the hamster is a polygene-controlled phenomenon and depends upon the presentation of differing parasite antigenic component(s) to the host.
KeywordsCellulose Acetate Humoral Immune Response Adult Worm Schistosoma Worm Burden
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