Zeitschrift für Parasitenkunde

, Volume 69, Issue 1, pp 41–51 | Cite as

Schistosoma mansoni infection of Syrian golden hamsters: The host humoral immune response in relation to the adult worm burdens after primary infection

  • W. K. Yong
  • P. K. Das
  • Y. P. Dachlan
Original Investigations
  • 28 Downloads

Abstract

Seven-week-old female Syrian golden hamsters (Mesocricetus auratus) showed different degrees of susceptibility toSchistosoma mansoni, as assessed by the percentage of cercariae recovered as adult worms 6 weeks after infection. Plasma of the low (A), medium (B) and high (C) susceptibility groups were tested immunochemically. No differences were observed in the concentrations of albumin, α1-, α2-, ;β- and γ-globulins as measured by cellulose acetate electrophoresis. However, a significantly higher percentage of animals in groups A and B than in group C had anS. mansoni specific “beforked” IgG precipitin band and specific antibodies against a worm tegumental antigen preparation (AWT).

Conversely, more animals in group C made antibodies against a “denuded” worm-body antigen preparation (AWB) than in groups A and B. However, by using the enzyme-linked immunosorbent assay, no significant differences in antibody titres against AWT, AWB and a total worm antigen (AVA) were observed in the animals in groups A, B and C.

Upon consideration of the immunochemical data in relation to the distribution pattern of susceptibility to infection, we propose that the intensity ofS. mansoni infection in the hamster is a polygene-controlled phenomenon and depends upon the presentation of differing parasite antigenic component(s) to the host.

Keywords

Cellulose Acetate Humoral Immune Response Adult Worm Schistosoma Worm Burden 

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • W. K. Yong
    • 1
  • P. K. Das
    • 1
    • 2
    • 3
  • Y. P. Dachlan
    • 1
  1. 1.International Immunology Training and Research CentreAmsterdamThe Netherlands
  2. 2.Department of Dermatology, Academic Medical CenterThe Municipal University of AmsterdamAmsterdam
  3. 3.Unit of ImmunochemistryThe National Institute of Public HealthBilthovenThe Netherlands

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