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Interferon-γ-activated immature macrophages exhibit a highTrypanosoma cruzi infection rate associated with a low production of both nitric oxide and tumor necrosis factor-α

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Abstract

Murine peritoneal macrophages (MPM) can be subdivided into two subpopulations of mature and immature macrophages. In contrast to mature macrophages, immature ones were highly susceptible toTrypanosoma cruzi infection. This high susceptibility was associated with a low production of α2-macroglobulin. Interferon-γ (IFN-γ)-activated immature macrophages also exhibited a higher infection rate than did IFN-γ-activated mature ones. This higher rate of infection was associated with a low production of both nitric oxide (N=O) and tumor necrosis factor-a (TFN-α). In contrast, mature MPM showed a lower rate of infection and produced higher levels of N=O and TFN-α. Taken together, these results show a clear-cut difference in the course ofT. cruzi infection in relation to the macrophage maturation state.

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  1. Laboratoire d'Immunologie (CP 615), Faculté de Médecine, U.L.B., 808 route de Lennik, B-1070, Brussels, Belgium

    N. Plasman, G. Metz & B. Vray

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  1. N. Plasman
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  2. G. Metz
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  3. B. Vray
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Plasman, N., Metz, G. & Vray, B. Interferon-γ-activated immature macrophages exhibit a highTrypanosoma cruzi infection rate associated with a low production of both nitric oxide and tumor necrosis factor-α. Parasitol Res 80, 554–558 (1994). https://doi.org/10.1007/BF00933002

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  • DOI: https://doi.org/10.1007/BF00933002

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