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The influence of thyroxine and propyl thiouracil onParastrongylus malaysiensis infection in rats

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Abstract

Daily intramuscular injection with thyroxine (T4) at a dose of 2.5 μg/100 g body weight decreased the larvae and adult worm burden ofParastrongylus malaysiensis in the brain and pulmonary arteries of male Sprague-Dawley albino rats. In contrast, rats treated with propyl thiouracil (PTU), an antithyroid drug, at a dose of 3.75 mg/100 g body weight retained greater numbers of larvae and adult worms. The results may reflect the contrasting immunomodulatory effects of T4 and PTU that influence the susceptibility of the host.

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Authors and Affiliations

  1. Jabatan Zoologi, University Kebangsaan Malaysia, 43600, Bangi, Malaysia

    A. B. Kamis, R. A. Ahmad & J. S. Chang

  2. Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia

    S. Ambu

Authors
  1. A. B. Kamis
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  2. R. A. Ahmad
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  3. J. S. Chang
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  4. S. Ambu
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Kamis, A.B., Ahmad, R.A., Chang, J.S. et al. The influence of thyroxine and propyl thiouracil onParastrongylus malaysiensis infection in rats. Parasitol Res 80, 87–88 (1994). https://doi.org/10.1007/BF00932632

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  • DOI: https://doi.org/10.1007/BF00932632

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