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Flucloxacillin compared with cefazolin in short-term prophylaxis for clean orthopedic surgery

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Summary

Two-hundred and fifty-two patients were included in a prospective, randomized, double-blind trial comparing the efficacy of flucloxacillin with that of cefazolin for clean orthopedic surgery. The preventive antibiotic regimen consisted of three 1-g injections perioperatively. There were 126 patients in each group, and the follow-up period was at least 6 months. Two deep (1.6%) and five superficial (4.0%) infections occurred in the flucloxacillin group. Three deep (2.4%) and five superficial (4.0%) infections developed in the cefazolin group.

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Authors and Affiliations

  1. Department of Orthopedic Surgery and Physical Medicine, Ghent University Hospital, De Pintelaan 185, B-9000, Ghent, Belgium

    J. Van Meirhaeghe, R. Verdonk & H. Claessens

  2. Department of Microbiology, Ghent University Hospital, De Pintelaan 185, B-9000, Ghent, Belgium

    G. Verschraegen, P. Myny & G. Paeme

Authors
  1. J. Van Meirhaeghe
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  2. R. Verdonk
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  3. G. Verschraegen
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  4. P. Myny
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  5. G. Paeme
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  6. H. Claessens
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Van Meirhaeghe, J., Verdonk, R., Verschraegen, G. et al. Flucloxacillin compared with cefazolin in short-term prophylaxis for clean orthopedic surgery. Arch Orthop Trauma Surg 108, 308–313 (1989). https://doi.org/10.1007/BF00932321

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