Parasitology Research

, Volume 79, Issue 4, pp 293–296 | Cite as

Immunizing potential of ultraviolet-attenuated cercariae ofSchistosoma mansoni in rodent hosts

  • Haruo Kamiya
  • Toshihiro Ozaki
  • Hideo Nakayama
  • Takashi Inaba
Article

Abstract

Schistosoma mansoni cercariae attenuated with ultraviolet (UV) irradiation (254 nm) at a dose of 18 mJ/cm2 induced partial resistance against a homologous challenge in male ICR mice and male Hartley guinea pigs. The reduction in the adult worm burden was 51% and 37%±13%, respectively. On the other hand, male and female Mongolian gerbils (Meriones unguiculatus) vaccinated with UV-attenuated cercariae exhibited marginal resistance (13%±9% and 22%±10%, respectively). This raises the possibility that gerbils might have an unknown immune-characteristic nature. The usefulness of UV-attenuated cercariae is discussed with respect to the control of the disease.

Keywords

Adult Worm Partial Resistance Schistosoma Mongolian Gerbil Worm Burden 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Haruo Kamiya
    • 1
  • Toshihiro Ozaki
    • 1
  • Hideo Nakayama
    • 1
  • Takashi Inaba
    • 1
  1. 1.Department of ParasitologyHirosaki University School of MedicineHirosakiJapan

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