Parasitology Research

, Volume 81, Issue 8, pp 631–637 | Cite as

Effects of PF1022A on adultAngiostrongylus cantonensis in the pulmonary arteries and larvae migrating into the central nervous system of rats

  • S. Kachi
  • A. Ishih
  • M. Terada
Original Paper

Abstract

We examined the effects of PF1022A, newly developing in Japan, on adultAngiostrongylus cantonensis in the pulmonary arteries of rats. Following five and ten successive oral doses at 10 mg/kg per day, the firststage larvae in rat faeces disappeared completely at 2 weeks after treatment. The treatment completely killed the female worms, but not the male worms. However, numbers of male worms were also decreased after the administration of either five successive oral doses at 10 mg/kg per day for four courses or five successive intraperitoneal doses at 0.5 mg/kg per day. Next, we examined the effects of PF1022A on larvalA. cantonensis migrating into the central nervous system (CNS) of rats. Following five successive oral doses at 5 or 10 mg/kg per day and five successive intraperitoneal doses at 0.5 mg/kg per day, lesser killing effects were observed on male as well as female worms. On the basis of these results it is apparent that PF1022A will become a promising anthelmintic available as treatment for tissuedwelling as well as intestinal nematodes.

Keywords

Nervous System Central Nervous System Pulmonary Artery Oral Dose Killing Effect 

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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • S. Kachi
    • 1
  • A. Ishih
    • 1
  • M. Terada
    • 1
  1. 1.Department of ParasitologyHamamatsu University School of MedicineHamamatsuJapan

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