Abstract
The effect of the monocyte locomotion inhibitory factor (MLIF) produced byEntamoeba histolytica is diminished, if not cancelled, when human monocytes are pre-exposed to concanavalin A or sodium periodate, respectively, but not when MLIF is pretreated with sodium periodate. When the MLIF-inhibited monocyte locomotion assays were performed in the presence of 12 different carbohydrates, only the runs containingd-mannose, 4-O-β-galactorsyl-mannoside or mannan revealed a significant reduction in the inhibitory effect. Finally, the MLIF activity was virtually absorbed out with mannan-coupled Sepharose 4B beads. This suggests thatd-mannose constitutes an essential part of the receptor for MLIF on the human monocyte membrane.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bar-Shavit Z, Ofek I, Goldman R, Mirelman D, Sharon N (1977) Mannose residues on phagocytes as receptor for the attachment ofE. coli andSalmonella typhi. Biochem Biophys Res Commun 78:455–460
Böyum A (1968) Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest 21 [Suppl 97]:31–50
Chadee K, Moreau F, Meerovitch E (1987)Entamoeba histolytica: chemoattractant activity for gerbil neutrophils in vivo and in vitro. Exp Parasitol 64:12–23
Dinarello CA (1988) Biology of interleukin 1. FASEB J 2:108–115
Ebert RH (1965) The experimental approach to inflammation. In: Zweifach BW, Grant L, McCluskey RT (eds) The inflammatory process. Academic Press, New York, pp 1–33
Everson-Pears AG (1972) Histochemistry, theoretical and applied, vol 2. Churchill Livingstone, Edinburgh
Giménez-Scherer JA, Pacheco-Cano MG, Cruz de Lavin E, Hernández-Jáuregui P, Merchant MT, Kretschmer RR (1987) Ultrastructural changes associated with the inhibition of monocyte chemotaxis caused by products of axenically grownE. histolytica. Lab Invest 57:45–51
Goldstein IJ, Hollerman CE, Smith EE (1965) Protein-carbohydrate interactions: II. Inhibition studies on the interaction of concanavalin A with polysaccharides. Biochemistry 4:876–883
Henry C, Una-Chen Y, Stout R, Swain SL (1980) Adherence. Nylon wool. In: Mishell BB, Shiigi SM (eds) Selected methods in cellular immunology. W.H. Freeman & Co., San Francisco, pp 182–185
Kawasaki T, Masayuki I, Yamashima I (1989) Galactose/N-acetyl galactosamine-binding protein and mannose/l-fucose/N-acetyl glucosamine-binding proteins from rat peritoneal macrophages. Methods Enzymol 179:322–327
Kretschmer RR (1986) Immunology of amebiasis. In: A Martinez-Palomo (ed) Amebiasis. Elsevier, Amsterdam, pp 95–167
Kretschmer R, Collado ML, Pacheco MG, Salinas MC, López-Osuna M, Lecuona M, Castro EM, Arellano J (1985) Inhibition of human monocyte locomotion by products of axenically grownE. histolytica. Parasite Immunol 7:527–543
Kretschmer RR, Castro EM, Rico G, Pacheco G, Noriega R, Arellano J (1989) Further characterization of a human monocyte locomotion inhibitory factor produced by axenically grownEntamoeba histolytica. Parasitol Res 75:245–246
Lotan R, Skutelsky E, Danon D, Sharon N (1975) The purification, composition and specificity of the anti-T lectin from peanut (Arachis hypogaea). J Biol Chem 250:8518–8523
Musher DM, Verbrugh HA, Verhoef J (1981) Suppression of phagocytosis and chemotaxis by cell wall components ofStaphylococcus aureus. J Immunol 127:84–88
Ofek I, Mirelman D, Sharon N (1977) Adherence ofE. coli to human mucosal cells mediated by mannose receptors. Nature 265:623–625
Ortiz-Ortiz L, Capin R, Capin NR, Sepúlveda B, Zamacona G (1978) Activation of the alternative pathway of complement byEntamoeba histolytica. Clin Exp Immunol 34:10–18
Papierniak C, Bourey RE, Kretschmer RR, Gotoff SP, Colombetti LG (1976) Technetium-99m labeling of human monocytes for chemotactic studies. J Nucl Med 17:988–992
Pérez-Tanayo R, Brandt H (1971) Amebiasis. In: Marcial-Rojas R (ed) Pathology of protozoan and helminthic diseases. Williams & Wilkins, Baltimore, pp 145–188
Ravdin JI (1989)Entamoeba histolytica: from adherence to enteropathy. J Infect Dis 159:420–429
Ravdin JI, Guerrant RL (1982) A review of the parasite cellular mechanisms involved in the pathogenesis of amebiasis. Rev Infect Dis 4:1185–1207
Remold HG (1973) Requirement for α-l-fucose on the macrophage membrane receptor for MIF. J Exp Med 138:1065–1076
Rico G, Diaz-Guerra I, Kretschmer RR (1990) Monocyte intracellular cyclic AMP changes caused by products of axenically grownE. histolytica. Arch Invest Med (Mex) (in press)
Salata RA, Pearson RD, Ravdin JI (1985) Interaction of human leukocytes andEntamoeba histolytica. Killing of virulent amebae by the activated macrophage. J Clin Invest 76:491–499
Schiffmann E, Corcoran BA, Wahl SM (1975)N-Formyl methionyl peptides as chemoattractants for leucocytes. Proc Natl Acad Sci USA 72:1059–1062
Sepúlveda B, Martínez-Palomo A (1982) Immunology of amebiasis byE. histolytica. In: Cohen S, Warren KS (eds) Immunology of parasitic disease. Blackwell Scientific, Oxford, pp 170–191
Sharon N (1984) Surface carbohydrates and surface lectins are recognition determinants in phagocytosis. Immunol Today 5:143–147
Siegel S (1956) Nonparametric statistics for behavioral sciences. McGraw Hill. New York, pp 116–127
Snyderman R, Altman LC, Hausman MS, Mergenhagen SE (1972) Human mononuclear leukocyte chemotaxis: a quantitative assay for humoral and cellular chemofactic factors. J Immunol 108:857–860
So LL, Goldstein IJ (1968) Protein carbohydrate interaction: XIII. The interaction of concanavalin A with mannans from a variety of microorganisms. J Biol Chem 243:2003–2007
Ward PA, (1968) Chemotaxis of mononuclear cells. J Exp Med 128:1201–1221
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kretschmer, R.R., Castro, E.M., Pacheco, G. et al. The role of mannose in the receptor of the monocyte locomotion inhibitory factor produced byEntamoeba histolytica . Parasitol Res 77, 374–378 (1991). https://doi.org/10.1007/BF00931631
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00931631