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Parasitology Research

, Volume 75, Issue 3, pp 186–188 | Cite as

Aminopeptidase activity in the brains of mice with chronicToxoplasma gondii infections

  • S. Akao
  • K. Yamakami
  • M. Nishiyama
  • M. Tanaka
Original Investigations

Abstract

Aminopeptidase activity on β-naphthylamide (NA) substrates was assayed in brain extracts from normal andToxoplasma gondii-infected mice at 4 months postinfection. Correlations of levels of aminopeptidase activity,Toxoplasma-specific antibody production, and the number of brain cysts were studied in normal andToxoplasma-infected mice. TheToxoplasma-specific antibody and the formation of cysts were markedly enhanced in the parasite-infected mice. The highest levels of activity for the NA substrates tested were observed in normal mice. In contrast, the activity levels were significantly lower inT. gondii-infected mice than in the corresponding normal mice. These results suggest an association between chronic toxoplasmosis and aminopeptidase activity in the parasite-infected host brain.

Keywords

Normal Mouse Antibody Production Toxoplasmosis Brain Extract Aminopeptidase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • S. Akao
    • 1
  • K. Yamakami
    • 1
  • M. Nishiyama
    • 1
  • M. Tanaka
    • 2
  1. 1.Department of ParasitologyNational Defense Medical CollegeTokorozawaJapan
  2. 2.Department of ParasitologyTsukuba UniversityIbarakiJapan

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