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Archives of Gynecology and Obstetrics

, Volume 241, Issue 2, pp 121–126 | Cite as

The significance of female sex steroids on the vascular permeability of the traumatised uterine serosa of rats

  • M. A. Gouveia
  • H. W. Halbe
  • N. Schutze Filho
Originals

Summary

Using experiments with conjugated hormones, and their influence on vascular permeability assessed by the colloidal carbon technique, we have investigated the effect of female sex steroids on the microcirculation of the uterine horn of virgin rats. We found that oestrogen inhibited vascular permeability in inflammatory conditions. Progesterone increased vascular permeability.

Key words

Vascular permeability Uterus Oestrogen Progesterone 

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References

  1. Almeida OP, Böhm GM (1979) Vascular permeability in the rat gingiva. A model of vessel response in chronic inflammation. J Pathol 127:27–33PubMedGoogle Scholar
  2. Bonta IL, Vos CJ de (1965) The effect of estriol-16-17-dihemisuccinate on vascular permeability as evaluated in the rat paw oedema test. Acta Endocrinol 49:403–411PubMedGoogle Scholar
  3. Bonta IL, Vargaftig BB, Böhm GM (1979) Snake venoms as an experimental tool to induce and study models of microvessel damage. In: Chen-Yuanlee (ed) Handbook of Experimental Pharmacology, vol 52. Springer, Berlin Heidelberg New YorkGoogle Scholar
  4. Clementson CAB, Blair LM, Reed DH (1962) Estrogen and capillary strength. Am J Obstet Gynaecol 83:1261–1268Google Scholar
  5. Friederici HHR (1967) The early response of uterine capillaries to estrogen stimulation. Lab Invest 17(3):322–333PubMedGoogle Scholar
  6. Gomel V (1983) Microsurgery in female infertility. Boston, Little BrownGoogle Scholar
  7. Gregório EA, Böhm GM, Bonta IL (1983) Morphological study of lesions induced by snake venoms (Naja naja and Akistridon piscivorus) in the pulmonary microcirculation of dogs. Microsc Electr Biol Cel 7:21–37Google Scholar
  8. Hempel KH, Fernandez LA, Persellin RH (1970) Effect of pregnancy on isolated lysosomes. Nature 225:955–956PubMedGoogle Scholar
  9. Ishioka T, Honda Y, Sagara A, Shimamoto T (1969) The effect of oestrogen on blueing lesions by bradykinin and histamine. Acta Endocrinol 49:403–411Google Scholar
  10. Lerner LJ, Carminati P, Schiati P (1975) Correlation of antiinflammatory activity with inhibition of prostaglandin synthesis activity of non-steroidal anti-estrogens and estrogens. Proc Soc Exp Biol Med 148:329–332PubMedGoogle Scholar
  11. Lurie MB (1950) Mechanisms affecting spread in tuberculosis. Ann NY Acad Sci 52:1074PubMedGoogle Scholar
  12. Maurer JH, Bonaventura LM (1983) The effect of aqueous progesterone on operative adhesion formation. Fertil Steril 39(4):485–489PubMedGoogle Scholar
  13. Mohamed AH, Waterhouse JP, Friederici HHR (1974) The microvasculature of rabbit gingiva as affected by progesterone: an ultrastructural study. J Periodont 45(1):50–60PubMedGoogle Scholar
  14. Rona G (1963) The role of vascular mucopolysacharides in the hemostatic action of estrogens. Am J Obstet Gynecol 87:434–436PubMedGoogle Scholar
  15. Schiff M, Burns HF (1961) The effect of intravenous estrogens on ground substance. Arch Otolaryngol 73:43–51PubMedGoogle Scholar
  16. Skelton F, Shute E, Skinner HG, Wand RA (1946) Antipruritic action of A-tocopherol (Vitamin E). Science 103:762Google Scholar
  17. Spector WG (1958) Substances which affect capillary permeability. Pharmacol Rev 10:475–505 laPubMedGoogle Scholar
  18. Vincent JE, Bonta IL, De Vries-Kragt K, Bhargava N (1970) L'influence des oestrogens sur perméabilité de la paroi vasculaire. Steroidologia 1:367–372Google Scholar
  19. Wilhelm DL (1973) Chemical mediators. In: Zweifach BW, Grant L, McCluskey RT (eds) The inflammatory process, 2rd edn. Academic Press, London New York, pp 251–301Google Scholar
  20. Ziskin DE, Nesse GJ (1946) Pregnancy gingivitis, history, classification, etiology. Am J Orthod Oral Surg 32:390Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • M. A. Gouveia
    • 1
  • H. W. Halbe
    • 2
  • N. Schutze Filho
    • 3
  1. 1.Laboratory of Experimental Pathology, Faculty of MedicineUniversity of São PauloSão PauloBrazil
  2. 2.Department of Obstetrics and Gynecology, Faculty of MedicineUniversity of São PauloSão PauloBrazil
  3. 3.Laboratory of Experimental Surgery, Faculty of MedicineUniversity of São PauloSão PauloBrazil

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