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In vitro analysis of Epstein-Barr virus: Host balance in patients with acutePlasmodium falciparum malaria

I. Defective T-cell control

Parasitology Research volume 76, pages 531–535 (1990)Cite this article

Abstract

Peripheral blood lymphocytes from healthy, Epstein-Barr virus (EB-virus)-seropositive donors and from patients with acutePlasmodium falciparum malaria were tested for their cytotoxicity towards autologous EB-virus-infected B-cells using an in vitro regression assay. Of the 18 cultures from control donors, 88.8% showed the normal pattern of regression. Of the 20 malaria patients in the study, 40% failed to exhibit the normal pattern observed in the control group. Analysis of the lymphocyte subsets showed a high incidence of inverted CD4∶CD8 ratios in the patient group due to an absolute rise in the CD8 population. This data suggests that the immunosuppressive effects of acute malaria extend to defective control over EB-virus. The relevance of the observations to the aetiology of EB-virusassociated, endemic Burkitt's lymphoma (eBL) is discussed.

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Author information

Affiliations

  1. Department of Haematology, The London Hospital Medical College, E1 2AD, London, UK

    D. E. Gunapala & C. A. Facer

  2. The Hospital for Tropical Diseases, NW1, London, UK

    R. Davidson

  3. Coppetts Wood Hospital, N10, London, UK

    W. R. C. Weir

Authors
  1. D. E. Gunapala
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  2. C. A. Facer
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  3. R. Davidson
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  4. W. R. C. Weir
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Gunapala, D.E., Facer, C.A., Davidson, R. et al. In vitro analysis of Epstein-Barr virus: Host balance in patients with acutePlasmodium falciparum malaria. Parasitol Res 76, 531–535 (1990). https://doi.org/10.1007/BF00931060

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  • DOI: https://doi.org/10.1007/BF00931060

Keywords

  • Malaria
  • Peripheral Blood Lymphocyte
  • Lymphocyte Subset
  • Immunosuppressive Effect
  • Normal Pattern