Abstract
Ultrastructural changes in the spores ofNosema apis were observed after infected honey bees were treated with itraconazole.Nosema spores from untreated honey bees developed normally, whereas those from treated bees exhibited many deformities. One particular feature noted was the absence of the polar filament. Lipid droplets were observed in the sporoplasm of treated spores. The significance of these observations in relation to the effectiveness of itraconazole againstN. apis is discussed.
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References
Ansehn S, Nilsson L (1984) direct membrane-damaging effect of ketoconazole and triconazole onCandida albicans demonstrated by bioluminescent assay of ATP. Antimicrob Agents Chemother 26:22–25
Brooks WM, Crawford JD, Pearce LW (1978) Benomyl: effectiveness against the microsporidianNosema heliothidis in the corn earworm,Heliothis zea. J Invertebr Pathol 31:239–245
Flint HM Eaton J, Klassen W (1972) The use of Fumidil B to reduce microsporidan disease in colonies of the boll weevil. Ann Entomol Soc Am 65:942–945
Katznelson H, Jamieson CA (1952) Control of nosema disease of honey bees with fumagillin. Science 115:70–71
Korn ED, Von Brand T, Tobie EJ (1969) The sterols ofTrypanosoma cruzi andCrithidia fasciculata. Comp Biochem Physiol B 30:601–610
Lewis L, Lynch R (1970) Treatment ofOstrinia nubilalis larvae with Fumidil B to controlPerezia pyraustae. J Invertebr Pathol 15:43–48
Liu TP (1985) Scanning electron microscope observations on the pathological changes of Malpighian tubules in the worker honey beeApia mellifera infected byMalpighamoeba mellificae. J Invertebr Pathol 46:125–132
Lui TP, Dixon SE (1973) Honey bee larval corpora allata: their fine structure and repressor action. J. Apic Res 12:167–178
McCabe RE, Remington JS, Araujo FG (1986) In vitro and in vivo effects of itraconazole againstTrypanosoma cruzi. Am J Trop Med Hyg 35:280–284
Moffett JO, Lackett JJ, Hitchcock JD (1969) Compounds tested for control ofNosema in the honey bees. J Econ Entomol 62:886–889
Olsen PE, Rice WA, Liu TP (1986) In vitro germination ofNosema apis spores under conditions favorable for the generation and maintenance of sporoplasms. J Invertebr Pathol 47:65–73
Saag MS, Dismukes WE (1988) Azole antifungal agents: emphasis on new triazole. Antimicrob Agents Chemother 32:1–8
Shadduck JA (1980) Effect of fumagillin on in vitro multiplication ofEncephalitozoan cuniculi. J Protozoon 27:202–208
Wilson GG (1974) The use of Fumidil B to suppress the microsporidianNosema fumiferanae in stock culture of the spruce budworm,Chroristoneura fumiferana (Lepidoptera: Tortricidae). Can Entomol 106:995–996
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Liu, T.P., Myrick, G.R. Deformities in the spore ofNosema apis as induced by itraconazole. Parasitol Res 75, 498–502 (1989). https://doi.org/10.1007/BF00930980
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DOI: https://doi.org/10.1007/BF00930980