Parasitology Research

, Volume 77, Issue 4, pp 320–324 | Cite as

Decrease of liver glycogen content in golden hamsters infected with plerocercoids ofSpirometra erinacei

  • T. Tsuboi
  • K. Hirai
  • M. Torii
  • H. Nishida
Original Investigations


Liver glycogen content decreased in golden hamsters experimentally infected with plerocercoids ofSpirometra erinacei. The activity of glycogen synthasea decreased significantly in infected animals, whereas that of glycogen phosphorylasea was not significantly affected. These observations suggest that changes in glycogen content were not attributable to increased glycogenolysis, but rather resulted from suppressed glycogenesis. Plasma immunoreactive insulin (IRI) concentrations in infected animals were slightly lower than those in controls, but the differences were not statistically significant. Plasma glucagon concentrations were significantly higher in infected animals. These results suggest that the suppression of glycogen synthase activity inS. erinacei-infected hamsters was attributable to enhanced levels of glucagon and that enhanced secretion of glucagon was caused by parasite-induced hypoglycemia.


Glucagon Hypoglycemia Infected Animal Glycogen Content Golden Hamster 
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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • T. Tsuboi
    • 1
  • K. Hirai
    • 1
  • M. Torii
    • 1
  • H. Nishida
    • 1
  1. 1.Department of ParasitologyEhime University School of MedicineEhimeJapan

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