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Chemotherapy of experimentalEchinococcus multilocularis in jirds

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Abstract

A total of 50 jirds (Meriones unguiculatus) were infected by intraperitoneal implantation of 0.20 g metacestode tissue ofEchinococcus multilocularis. The feed of 4 groups of 10 animals each was treated for 35 days with 500 ppm albendazole, flubendazole, mebendazole or praziquantel; 1 group of 10 jirds served as unmedicated controls. At autopsy 2 weeks after the end of medication, the transplants had increased in size and weight, reaching a total weight of 78.11 g in the control group, 21.60 g in the albendazole-treated group, 3.63 g in the flubendazole-treated group, 7.00 g in the mebendazole-treated group and 68.91 g in the praziquantel-treated group. The percentage in reduction of parasitic tissue weight as compared with control values was 72%, 95%, 91% and 12%, respectively. The calculated daily drug intake was approximately 48 mg/kg body weight. Drug-related side effects were not observed.

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Authors and Affiliations

  1. Department of Parasitology, Janssen Pharmaceutica, B-2340, Beerse, Belgium

    O. Vanparijs

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  1. O. Vanparijs
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Vanparijs, O. Chemotherapy of experimentalEchinococcus multilocularis in jirds. Parasitol Res 76, 238–240 (1990). https://doi.org/10.1007/BF00930820

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  • DOI: https://doi.org/10.1007/BF00930820

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