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Study of the interaction of acridine with α-chymotrypsin by the method of fluorescence

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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    The fluorescence of acridine in aqueous medium and in a number of organic solvents, as well as that of acridine bound in the adsorption site of α-chymotrypsin, was studied.

  2. 2.

    Acridine bound to α-chymotrypsin is in contact with proton donor groups in the hydrogen bond, possessing reduced proton donor properties.

  3. 3.

    Complexes of α-chymotrypsin and acridine, formed in aqueous medium and in anhydrous DMSO, possess close fluorescent properties.

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Authors and Affiliations

  1. N. D. Zelinskii Institute of Organic Chemistry, Academy of Sciences of the USSR, Moscow

    A. N. Nikitina, Yu. I. Khurgin & Yu. M. Azizov

Authors
  1. A. N. Nikitina
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  2. Yu. I. Khurgin
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  3. Yu. M. Azizov
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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 7, pp. 1517–1522, July, 1974.

The authors would like to express their gratitude to D. I. Ivashchenko, T. V. Sinyavskaya, and S. V. Baranovskaya for their aid in performing the measurements.

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Nikitina, A.N., Khurgin, Y.I. & Azizov, Y.M. Study of the interaction of acridine with α-chymotrypsin by the method of fluorescence. Russ Chem Bull 23, 1438–1441 (1974). https://doi.org/10.1007/BF00929647

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  • DOI: https://doi.org/10.1007/BF00929647

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