Conclusions
-
1.
The reaction of 2,5,6-triamino-4-hydroxypyrimidine with the bromination products of N-aeetylaminoacetone and N-acetyl-3-amino-2-butanone respectively gave a mixture of the 6- and 7-methylpterins and 6, 7-dimethylpterin.
-
2.
The reaction of N-acetylaminoacetone with paraform and piperidine leads to the formation of N-acetyl-2 amino-1-buten-3-one, which on acid hydrolysis gives dimethylglyoxal.
This is a preview of subscription content, log in via an institution to check access.
Literature cited
S. I. Zav'yalov, N. I. Makhova, N. I. Aronova, and I. F. Mustafaeva, Izv. Akad. Nauk SSSR, Ser. Khim., 2826 (1971).
S. I. Zav'yalov, N. I. Aronova, and I. F. Mustafaeva, Izv. Akad. Nauk SSSR, Ser. Khim., 1674 (1972).
W. Pfleiderer, H. Zondler, and R. Mengel, Liebigs Ann. Chem.,483, 259 (1930).
T. Sachs and G. Meyerheim, Ber.,41, 3965 (1908).
S. I. Zav'yalov, M. P. Unanyan, G. V. Kondrat'eva, and V. V. Filippov, Izv. Akad. Nauk SSSR, Ser. Khim., 1792 (1967).
H. V. Pechmann, Ber.,20, 2543 (1887).
S. I. Zav'yalov, N. I. Aronova, and N. N. Makhova, RIMIOS, Vol. 22, Khimiya (1971), p. 18.
R. Fittig, C. Daimler, and H. Keller, Liebigs Ann. Chem.,249, 203 (1888).
C. K. Cain, M. F. Mallette, and E. C. Taylor, J. Am. Chem. Soc.,68, 1996 (1946).
V. M. Berezovskii and L. I. Strel'china, Tr. Vses. Nauchn. Issled. Vitamin. Inst.,5, 28 (1954).
Author information
Authors and Affiliations
Additional information
Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 9, pp. 2136–2138, September, 1973.
We express our gratitude to K. B. Storm (USA) and W. Pfleiderer (Germany) for graciously supplying the samples of compounds (VIII) and (IX).
Rights and permissions
About this article
Cite this article
Zav'yalov, S.I., Budkova, T.K. & Aronova, N.I. Synthesis of pterins from N-acyl-α-amino ketones. Russ Chem Bull 22, 2084–2086 (1973). https://doi.org/10.1007/BF00929414
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00929414