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Reaction of S-(ω-ethylmercaptoalkyl) diphenyl thiophosphinates, O-(ω-ethylmercaptoalkyl) diphenyl phosphinates, and their methiodides with cholinesterase from horse blood serum

  • Organic and Biological Chemistry
  • Published:
Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    We determined the kinetic constants for the combined inhibition of butyrylcholinesterase by diphenyl thiophosphinates (C6H5)2P(O)S(CH2)nSC2H5 and their methiodides\((C_6 H_5 )_2 P(O)S(CH_2 )n\mathop S\limits^ \oplus (CH_3 )C_2 H_5 \cdot I^-- \), with n=2–6, and also the reversible inhibition constants for the analogous oxygen esters.

  2. 2.

    The ability of diphenyl thiophosphinates, diphenyl phosphinates, and their methiodides, to undergo reversible sorption on the active surface of the enzyme is enhanced with increase in the number of CH2 groups. In the sulfide series of thioesters the irreversible inhibition rate constants remain practically unchanged with increase in the number of CH2 groups, while in the sulfonium series they decrease symbatically with decrease in their alkaline hydrolysis rate constants.

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Literature cited

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Authors and Affiliations

  1. Institute of Heteroorganic Compounds, Academy of Sciences of the USSR, USSR

    R. I. Volkova, N. A. Kardanov, A. P. Brestkin, N. N. Godovikov & M. I. Kabachnik

  2. I. M. Sechenov Institute of Evolutional Physiology and Biochemistry, Academy of Sciences of the USSR, USSR

    R. I. Volkova, N. A. Kardanov, A. P. Brestkin, N. N. Godovikov & M. I. Kabachnik

Authors
  1. R. I. Volkova
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  2. N. A. Kardanov
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  3. A. P. Brestkin
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  4. N. N. Godovikov
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  5. M. I. Kabachnik
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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 9, pp. 2114–2119, September, 1973.

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Volkova, R.I., Kardanov, N.A., Brestkin, A.P. et al. Reaction of S-(ω-ethylmercaptoalkyl) diphenyl thiophosphinates, O-(ω-ethylmercaptoalkyl) diphenyl phosphinates, and their methiodides with cholinesterase from horse blood serum. Russ Chem Bull 22, 2058–2062 (1973). https://doi.org/10.1007/BF00929405

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  • DOI: https://doi.org/10.1007/BF00929405

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