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Ionization potentials of phenothiazine derivatives and their correlation with the pharmacological effect

  • Organic and Biological Chemistry
  • Published:
Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    The ionization potentials (I) of some phenothiazine derivatives (PTD) were calculated from the optical spectra of the charge-transfer complexes.

  2. 2.

    The obtained values were compared with the indices that characterize the cholinolytic and antiarrhythmic properties of the PTD, and it was concluded that a relation exists between them.

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Literature cited

  1. G. Karremann, I. Isenberg, and A. Szent-Gyorgi, Science,130, 1191 (1959).

    PubMed  Google Scholar 

  2. D. H. Kearns and M. Calvin, J. Chem. Phys.,34, 2026 (1961).

    Google Scholar 

  3. L. F. Lyons and L. G. Mackie, Nature,197, 589 (1963).

    PubMed  Google Scholar 

  4. F. Gutmann and H. Keyzer, Agressologie,9, 27 (1968).

    PubMed  Google Scholar 

  5. K. R. Merril, S. H. Snyder, and D. F. Bradley, Biochim. Biophys. Acta,118, 316 (1966).

    PubMed  Google Scholar 

  6. E. D. Bergmann, Ann. N. Y. Acad. Sci.,58, 140 (1969).

    Google Scholar 

  7. A. P. Poltorakov, P. G. But, L. A. Piruzyan, V. M. Chibrikin, Yu. I. Vikhlyaev, and O. V. Ul'yanova, Izv. Akad. Nauk SSSR, Ser. Khim., 2099 (1973).

  8. V. N. Vedeneev, L. V. Gurvich, V. N. Kondrat'ev, V. A. Medvedev, and E. L. Frankevich, in: Cleavage Energy of Chemical Bonds. Ionization Potentials and Electron Affinity [in Russian], Izd. AN SSR (1962).

  9. E. M. Cosover, New Problems in Physical Organic Chemistry [Russian translation], Mir (1969), p. 53.

  10. L. Andrews and R. Kieffer, Molecular Complexes in Organic Chemistry [Russian translation], Mir (1967), p. 140.

  11. Organic Semiconductors [in Russian], Nauka (1968), p. 340.

  12. R. P. Cook, J. Physiol. (London),62, 160 (1926).

    Google Scholar 

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Authors and Affiliations

  1. Institute of Chemical Physics, Academy of Sciences of the USSR, USSR

    A. P. Poltorakov, F. N. Pirnazarova, P. G. But, L. A. Piruzyan, V. M. Chibrikin, Yu. I. Vikhlyaev & O. V. Ul'yanova

  2. Institute of Pharmacology, Academy of Medical Sciences of the USSR, USSR

    A. P. Poltorakov, F. N. Pirnazarova, P. G. But, L. A. Piruzyan, V. M. Chibrikin, Yu. I. Vikhlyaev & O. V. Ul'yanova

Authors
  1. A. P. Poltorakov
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  2. F. N. Pirnazarova
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  3. P. G. But
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  4. L. A. Piruzyan
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  5. V. M. Chibrikin
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  6. Yu. I. Vikhlyaev
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  7. O. V. Ul'yanova
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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 9, pp. 2106–2110, September, 1973.

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Poltorakov, A.P., Pirnazarova, F.N., But, P.G. et al. Ionization potentials of phenothiazine derivatives and their correlation with the pharmacological effect. Russ Chem Bull 22, 2050–2053 (1973). https://doi.org/10.1007/BF00929403

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  • DOI: https://doi.org/10.1007/BF00929403

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