Conclusions
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1.
The chemical synthesis of some uridine diphosphate glucose analogs, and specifically the 5-hydroxy-, 5-amino-, 5-chloro-, 5-bromo-, 5-iodo-, and 5-methoxyuridine derivatives, was accomplished.
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2.
It was shown that the morpholide method of synthesizing pyrophosphates can be used for the preparation of the 5-halo- and 5-aminouridine derivatives. The progress of a side reaction was observed in the latter case. It was shown that the method cannot be used for the 5-hydroxyuridine derivatives.
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3.
Conditions were developed for the synthesis of nucleoside diphosphate sugars via the nucleoside 5-imidazolides and it was shown that this method has wide application.
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 9, pp. 2095–2099, September, 1973.
See[1] for Communication 16.
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Shibaev, V.N., Eliseeva, G.I. & Kochetkov, N.K. Analogs of carbohydrate metabolism coenzymes Communication 17. Some C-5 substituted heterocyclic analogs of uridine diphosphate glucose. Russ Chem Bull 22, 2039–2043 (1973). https://doi.org/10.1007/BF00929401
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DOI: https://doi.org/10.1007/BF00929401