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Synthesis, study of configuration and reactivity of amino acids, acylated by p-[DI-(2-chloroalkyl)amino]cinnamic acid

  • Organic and Biological Chemistry
  • Published:
Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    The following compounds were synthesized; p-[di-(2-chloropropyl)amino]cinnamoyl-DL-phenyl-alanine and its ethyl ester, p-[di-(2-chloropropyl)amino]cinnamoyl-DL-valine, the methyl ester of p-[di-(2-chloropropyl) amino]cinnamoyl-L-histidine, p-[di-(2-chloropropyl)amino]cinnamoyl-p-aminobenzoic acid and its ethyl ester, and also p-[di-(2-chloroethyl)amino]cinnamoyl-p-aminobenzoic acid and its ethyl ester.

  2. 2.

    The hydrolysis rate of the C-Cl bond in the cytotoxic groups of the synthesized compounds was measured.

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Literature cited

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Authors and Affiliations

  1. Institute of Heteroorganic Compounds, Academy of Sciences of the USSR, USSR

    K. I. Karpavichyus, G. I. Prasmitskene, A. M. Yuodvirshis, L. Ya. Gurvichene & O. V. Kil'disheva

  2. Institute of Biochemistry, Academy of Sciences of the Lithuanian SSR, USSR

    K. I. Karpavichyus, G. I. Prasmitskene, A. M. Yuodvirshis, L. Ya. Gurvichene & O. V. Kil'disheva

Authors
  1. K. I. Karpavichyus
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  2. G. I. Prasmitskene
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  3. A. M. Yuodvirshis
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  4. L. Ya. Gurvichene
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  5. O. V. Kil'disheva
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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 9, pp. 2067–2071, September, 1973.

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Karpavichyus, K.I., Prasmitskene, G.I., Yuodvirshis, A.M. et al. Synthesis, study of configuration and reactivity of amino acids, acylated by p-[DI-(2-chloroalkyl)amino]cinnamic acid. Russ Chem Bull 22, 2012–2016 (1973). https://doi.org/10.1007/BF00929394

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  • DOI: https://doi.org/10.1007/BF00929394

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