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Signal transduction inTrypanosoma cruzi: opposite effects of adenylcyclase and phospholipase C systems in growth control

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Abstract

Fetal calf serum (FCS), which is mitogenic for the pathogenic protozoaT. cruzi, inhibits cAMP production in basal and forskolin-stimulated epimastigotes. It also activates phosphoinositides hydrolysis yielding diacylglycerol and inositol phosphates (Ins-P). Ins-P production is enhanced by AlF4-, GTP or β-γ-methylene-GTP, thus implying G proteins mediation in the phenomenon. An enzyme with phospholipase C activity which may be involved in the phospholipid metabolism was partially characterized.

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Authors and Affiliations

  1. Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21949-900 Rio, de Janeiro, Brazil

    Mecia M. Oliveira, Eliane D. Rocha, Edson Rondinelli, Andrea V. Arnholdt & Julio Scharfstein

Authors
  1. Mecia M. Oliveira
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  2. Eliane D. Rocha
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  3. Edson Rondinelli
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  4. Andrea V. Arnholdt
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  5. Julio Scharfstein
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Oliveira, M.M., Rocha, E.D., Rondinelli, E. et al. Signal transduction inTrypanosoma cruzi: opposite effects of adenylcyclase and phospholipase C systems in growth control. Mol Cell Biochem 124, 91–99 (1993). https://doi.org/10.1007/BF00929200

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  • DOI: https://doi.org/10.1007/BF00929200

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