A mathematical model based on kinetic data taken from the literature is presented for the pentose phosphate pathway in fasted rat liver steady-state. Since the oxidative and non oxidative pentose phosphate pathway can act independently, the complete (oxidative + non oxidative) and the non oxidative pentose pathway were simulated.
Sensitivity analyses are reported which show that the fluxes are mainly regulated by D-glucose-6-phosphate dehydrogenase (for the oxidative pathway) and by transketolase (for the non oxidative pathway). The most influent metabolites were the group ATP, ADP, P1 and the group NADPH, NADP+ (for the non oxidative pathway).
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Glucokinase, (E.C. 126.96.36.199.)
D-glucose-6-phosphate dehydrogenase, (E.C. 188.8.131.52)
6-Phosphogluconelactonase, (E.C. 184.108.40.206.)
6-Phosphogluconate dehydrogenase, (E.C. 220.127.116.11)
D-ribose-5-phosphate keto-isomerase, (E.C. 18.104.22.168)
D-sedoheptulose-7-phosphate: D-glyceraldehyde-3-phosphate glycol-aldehyde transferase, (E.C. 22.214.171.124.)
D-sedoheptulose-7-phosphate: D-glyceraldehyde-3-phosphate dihydroxyacetone transferase, (E.C. 126.96.36.199)
D-ribulose-5-phosphate-3′-epimerase, (E.C. 188.8.131.52)
D-glucose-6-phosphate keto-isomerase, (E.C. 184.108.40.206)
D-glyceraldehyde-3-phosphate keto-isomerase, (E.C.220.127.116.11)
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Sabate, L., Franco, R., Canela, E.I. et al. A model of the pentose phosphate pathway in rat liver cells. Mol Cell Biochem 142, 9–17 (1995). https://doi.org/10.1007/BF00928908
- control coefficients
- logarithmic gains
- pentose phosphate