Abstract
To evaluate the role of parathyroids in calculus disease, the parathyroid hormone levels were determined in 22 control subjects and 42 stone (14 with bladder stone and 28 with kidney stone) patients. Serum calcium, inorganic phosphate, alkaline phosphatase and parathyroid hormone and urinary excretion of calcium and inorganic phosphate were determined. It was found that normocalcemic and normocalciuric stone patients had slightly higher levelsss of parathyroid hormone (irrespective of the site of the stone) and the difference was not statistically significant as compared with control subjects although some of the patients with calculus disease were hyperparathyroid. Serum alkaline phosphatase was increased while there was an increase in urinary calcium excretion in kidney stone patients and oxalate in all patients as compared with control subjects. The increase in inorganic phosphate was, however, not different from the control subjects. The subclinical hyperparathyroidism and stone formation in these patients are not correlated.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Albright F, Sulkowitch NW, Bloomberg E: Further experience in the diagnosis of hyperparathyroidism. Am J Med Sc 193:800, 1937
Pyrah LN: The calcium containing renal stone. Proc Soc Med 51: 183–201, 1958
Albuquerque PF, Forster R, Zanandrea R: Etiological factors in urolithiasis. A clinical analysis of 275 cases. J Urol 89: 325–328, 1963
Mohr Retheel, Graif M, Itzchak Y, Dreznick Z, Dolev F, Charve I, Wolfstein I: Parathyroid localisation — sonographic surgical correlation. Am Surg 51 (5): 286–290, 1985
Agus ZS, Gardner LB, Beek LH, Goldberg M: Effect of parathyroid hormone on renal tubular reabsorption of calcium, sodium and phosphate. Am J Physiol 224:1143–1148, 1973
Martin DW, Mayes PA, Rodwell VW: In: Maruzen Asia (Pte) Ltd., Harper's Reviews of Biochemistry, 18th Edition, Lange Medical Publications, Singapore, 1981, p 474
Shahjehan S, Rahman MA: Studies on the etiology of urolithiasis in Karachi. Am J Clin Nutr 24: 32–37, 1971
Khanam A, Rahman MA: The studies on inorganic composition of urinary calculi. Asean J Clin Sci 7: 73–80, 1987
Rahman B, Rahman MA: Changes in urinary composition of calcium oxalate stone formers. Biomed Pharmacotherapy 40: 108–110, 1986
Bauer JD, Toro G, Ackermann PG: In: ‘Bray's Clinical aboratory Methods’, 6th Edition, Mosby, St. Louis, USA, 1962, p 310
Varley H: ‘Practical Clinical Biochemistry’, 3rd Edition, Interscience Publishers, New York, 1962, p 348–350, 156–157, 110–111
Amador E, Zimmermann S, Wacker WE: Urinary alkaline phosphatase activity. JAMA 185: 769–775, 1963
Singh SN: Studies on vesical calculus disease in India. Proc WHO Regional Symposium on Vesical Calculus, Editor: Van Reen, DHEW Publication No. (NIH) 77-1191, USA, 1972, p 68–78
Lauffenberg BV, Wacker THR: Normocalcaemic nephrolithiasis and primary hyperparathyroidism. Excerpta Medica 41 (1): 45, 1979
Almqvist S, Hijern B, Wasthed B: The diagnostic value of radioimmunoassay of PTH in human serum. Acta Endocrinol78: 493–509, 1975
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Khanam, A., Rahman, M.A. Parathyroid hormone in urinary stone patients. Mol Cell Biochem 121, 1–4 (1993). https://doi.org/10.1007/BF00928693
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00928693