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Reaction of O-ethyl-S-(β-alkylmercaptoethl)-cyclohexylthiophosphonates and their iodomethylates with choline sterases

  • Organic Chemistry
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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

O-Ethyl-S-(β-alkylmercaptoethyl)cyclohexylthiophosphonates are inhibitors of acetylcholinesterase and butyrylcholinesterase with a combinative type of action. The iodomethylates of O-ethyl-S-(β-alkylmercaptoethyl) cyclohexylthiophosphonates inhibit acetylcholinesterase irreversibly, and butyrylcholinesterase according to a combinative type of inhibition.

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Literature cited

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Authors and Affiliations

  1. Institute of Heteroorganic Compounds, Academy of Sciences of the USSR, Moscow

    V. M. Kuzamyshev, M. Kh. Berkhamov, N. N. Godovikov, R. S. Agabekyan, E. G. Kireeva, Z. K. Pegova & M. I. Kabachnik

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  1. V. M. Kuzamyshev
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  2. M. Kh. Berkhamov
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  3. N. N. Godovikov
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  4. R. S. Agabekyan
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  5. E. G. Kireeva
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  6. Z. K. Pegova
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  7. M. I. Kabachnik
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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskayaj No. 7, pp. 1600–1606, July, 1977.

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Kuzamyshev, V.M., Berkhamov, M.K., Godovikov, N.N. et al. Reaction of O-ethyl-S-(β-alkylmercaptoethl)-cyclohexylthiophosphonates and their iodomethylates with choline sterases. Russ Chem Bull 26, 1471–1476 (1977). https://doi.org/10.1007/BF00928531

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  • DOI: https://doi.org/10.1007/BF00928531

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