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Cyclosporin A and C

New metabolites fromTrichoderma polysporum (Link ex Pers.) Rifai


Cyclosporin A and C are new antifungal antibiotics fromTrichoderma polysporum (Link ex Pers.) Rifai. The metabolites are produced in submerged culture and are extracted therefrom by organic solvents. Cyclosporin A is a nonpolar cyclic peptide with a molecular weight of 1202.6. The cyclosporins exhibit a narrow spectrum of antifungal activity and in addition have immunosuppressive properties.

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Dreyfuss, M., Härri, E., Hofmann, H. et al. Cyclosporin A and C. European J. Appl Microbiol. 3, 125–133 (1976).

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  • Peptide
  • Molecular Weight
  • Cyclosporin
  • Organic Solvent
  • Antifungal Activity