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Chitin metabolism: a target for drugs against parasites

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Abstract

Chitin is an important component of the exoskeleton of arthropods and of the egg shell in nematodes, but it does not occur in vertebrates. Therefore, it represents a useful target for drugs against ectoparasitic crustaceans, insects and endoparasitic nematodes. In this review we describe the basic characteristics of chitin, chitin synthesis and degradation and the hormonal regulation of chitin metabolism. Substances interfering with chitin metabolism like benzoylphenyl-urea derivatives but also some recently detected compounds are described. The necessity for a more detailed understanding of chitin metabolism and the establishment of better model systems, like e.g. chitin producing insect cell lines, is stressed and some examples are given in this review.

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Authors and Affiliations

  1. Institut für Zoologie, Lehrstuhl für Hormon- und Entwicklungsphysiologie, Heinrich-Heine-Universität Düsseldorf, D-4000, Dusseldorf 1, Germany

    Klaus-Dieter Spindler

  2. Institut für Zoologie, Abteilung Parasitologie, Heinrich-Heine-Universität Düsseldorf, D-4000, Düsseldorf 1, Germany

    Margarethe Spindler-Barth

  3. Abteilung VT-FE-F, Bayer AG, Pflanzenschutzzentrum, D-5090, Leverkusen, Germany

    Michael Londershausen

Authors
  1. Klaus-Dieter Spindler
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  2. Margarethe Spindler-Barth
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  3. Michael Londershausen
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Dedicated to Prof. Werner Peters (Düsseldorf) for his 60th birthday

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Spindler, KD., Spindler-Barth, M. & Londershausen, M. Chitin metabolism: a target for drugs against parasites. Parasitol Res 76, 283–288 (1990). https://doi.org/10.1007/BF00928180

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