Retention and egg production ofMicrophallus pygmaeus in mice: the influence of the adrenal cortex
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Fewer adultMicrophallus pygmaeus are recovered from the small intestine of adrenalectomized male mice than from sham-operated counterparts. Preinfection intraperitoneal injection of 2 IU or 4 IU ACTH adaily for 7 days increases the initial primary worm burden in male mice. Preinfection intramuscular injection of 325 μg corticosterone daily for 7 days increases the initial worm burden and alters the subsequent rate of decline and duration of the primary infection. However, egg production is unaffected. The changes in parasite numbers are attributed to the immunosuppressive action of corticosterone.
KeywordsSmall Intestine Corticosterone Intraperitoneal Injection Male Mouse Intramuscular Injection
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- Ahmad RA (1984) Studies on marine digenea in experimental hosts:Microphallus pygmaeus (Levinsen 1881) in the laboratory mouse. PhD thesis, University of WalesGoogle Scholar
- Ahmed Z, Saleh M, Siddiqui F (1970) A comparative study of the effects of ACTH, hydrocortisone and prednisolone in the hypersensitive reactions produced with the protein components ofHymenolepis nana in albino mice. Rev Parasitol 31:117–122Google Scholar
- Baughn CO (1952) The effect of adrenalectomy on natural and acquired resistance of mice toTrichinella spiralis. J Elisha Mitchell Sci Soc 68:207–221Google Scholar
- Esch GW (1967) Some effects of cortisone and sex on the biology of coenuriasis in laboratory mice and jack rabbits. Parasitology 57:175–179Google Scholar
- Gibson DI (1979) Materials and methods in helminth alpha-taxonomy. Parasitology 79:XXXVIGoogle Scholar
- McKeerns KW (1968) Mechanisms of ACTH regulation of the adrenal cortex. In: McKeerns KW (ed) Functions of the adrenal cortex, North Holland, Amsterdam, p 479Google Scholar
- Nie NH, Hull CH, Jenkins JG, Steinbrenner K, Bent DH (1975) Statistical package for the social services, McGraw-Hill, LondonGoogle Scholar