Advertisement

Zeitschrift für Parasitenkunde

, Volume 72, Issue 4, pp 479–485 | Cite as

Retention and egg production ofMicrophallus pygmaeus in mice: the influence of the adrenal cortex

  • Rohani A. Ahmad
  • B. L. James
  • A. B. Kamis
Original Investigations

Abstract

Fewer adultMicrophallus pygmaeus are recovered from the small intestine of adrenalectomized male mice than from sham-operated counterparts. Preinfection intraperitoneal injection of 2 IU or 4 IU ACTH adaily for 7 days increases the initial primary worm burden in male mice. Preinfection intramuscular injection of 325 μg corticosterone daily for 7 days increases the initial worm burden and alters the subsequent rate of decline and duration of the primary infection. However, egg production is unaffected. The changes in parasite numbers are attributed to the immunosuppressive action of corticosterone.

Keywords

Small Intestine Corticosterone Intraperitoneal Injection Male Mouse Intramuscular Injection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adams DB, Davies HI (1982) Enhanced to infection withHaemonchus contortus in sheep treated with a corticosteroid. Int J Parasitol 12:523–529PubMedGoogle Scholar
  2. Ahmad RA (1984) Studies on marine digenea in experimental hosts:Microphallus pygmaeus (Levinsen 1881) in the laboratory mouse. PhD thesis, University of WalesGoogle Scholar
  3. Ahmed Z, Saleh M, Siddiqui F (1970) A comparative study of the effects of ACTH, hydrocortisone and prednisolone in the hypersensitive reactions produced with the protein components ofHymenolepis nana in albino mice. Rev Parasitol 31:117–122Google Scholar
  4. Balow JE, Hurley DL, Fauci AS (1975) Immunosuppressive effects of glucocorticoids: Differential effects of actue versus chronic administration on cell mediated immunity. J Immunol 114:1072–1076PubMedGoogle Scholar
  5. Baughn CO (1952) The effect of adrenalectomy on natural and acquired resistance of mice toTrichinella spiralis. J Elisha Mitchell Sci Soc 68:207–221Google Scholar
  6. Brayton AR, Brain PF (1974) Effects of “crowding” on endocrine function and retention of the digenean parasiteMicrophallus pygmaeus in male and female albino mice. J Helminthol 48:99–106PubMedGoogle Scholar
  7. Cummins RO, Suratt PM, Horwitz DA (1978) DisseminatedStrongyloides stercoralis infection. Association with ectopic ACTH syndrome and depressed cell-mediated immunity. Arch Intern Med 138:1005–1006PubMedGoogle Scholar
  8. Esch GW (1967) Some effects of cortisone and sex on the biology of coenuriasis in laboratory mice and jack rabbits. Parasitology 57:175–179Google Scholar
  9. Fortier C, De Groot J (1959) Adenohypophyseal corticotrophin and plasma free corticosteroids during regeneration of the enucleated rat adrenal gland. Am J Physiol 196:589–592PubMedGoogle Scholar
  10. Gibson DI (1979) Materials and methods in helminth alpha-taxonomy. Parasitology 79:XXXVIGoogle Scholar
  11. Hashiguchi Y Hirai H (1977) Influence of immunosuppressants on the establishment ofParagonimus miyazakii in albino rats. J Helminthol 51:87–94PubMedGoogle Scholar
  12. Hopkins CA, Subraminiam G, Stallard H (1972) The effect of immunosuppressants on the development ofHymenolepis diminuta in micei. Parasitol 65:111–120PubMedGoogle Scholar
  13. McKeerns KW (1968) Mechanisms of ACTH regulation of the adrenal cortex. In: McKeerns KW (ed) Functions of the adrenal cortex, North Holland, Amsterdam, p 479Google Scholar
  14. Michel JF, Sinclair IJ (1969) The effect of cortisone on the worm burdens of calves infected daily withOstertagia ostertagia. Parasitology 59:691–708PubMedGoogle Scholar
  15. Mills AR, Brain PF, James BL (1973)Microphallus pygmaeus: Effect of long-acting ACTH preparation on establishment and retention in alimentary canal of the mouse. Exp Parasitol 34:251–256PubMedGoogle Scholar
  16. Moss GD (1972) The effect of cortisone acetate treatment on the growth ofHymenolepis microstoma in mice. Parasitology 64:311–320PubMedGoogle Scholar
  17. Nie NH, Hull CH, Jenkins JG, Steinbrenner K, Bent DH (1975) Statistical package for the social services, McGraw-Hill, LondonGoogle Scholar
  18. Nussdorfer GG, Mazzochi G (1972) A stereologic study of the effects of ACTH and cyclid 3′, 5′-AMP on adrenocortical cells of intact and hypophysectomized rats. Lab Invest 26:45–52PubMedGoogle Scholar
  19. Ritterson AL, Concannon J (1968) Comparative effects of cortisone and ACTH on golden and Chinese hamsters infected withTrichinella spiralis. J Parasitol 54:822–826PubMedGoogle Scholar
  20. Sinclair KB (1968) The effect of corticosteroid on the pathogenicity and development ofFasciola hepatica in lambs. Br Vet J 124:133–139PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Rohani A. Ahmad
    • 1
  • B. L. James
    • 2
  • A. B. Kamis
    • 1
  1. 1.Jabatan ZoologyUniversiti Kebangsaan MalaysiaSelangorMalaysia
  2. 2.Department of ZoologyUniversity College of SwanseaSwanseaUK

Personalised recommendations