Skip to main content
SpringerLink
Log in

Immunoglobulin levels in various clinical groups of human Brugian filariasis in Malaysia

  • Original Investigations
  • Published:
Zeitschrift für Parasitenkunde Aims and scope Submit manuscript

Abstract

Quantitation of serum immunoglobulin M, G, A, D and E levels was carried out in Malaysians withBrugia malayi infections. Results showed highly elevated levels of IgM and IgE as well as moderately elevated levels of IgG. These were most significant in patients with tropical pulmonary eosinophilia or elephantiasis. Serum IgE levels were extremely high in microfilaraemic patients (6,060±3.958 IU ml) probably due to a constant antigenic stimulation by dead and dying microfilariae.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Mak JW (1978) Studies on filariasis amongst Orang Asli in Peninsular Malaysia, with special reference to chemotherapy, M.D. Thesis, University of Singapore

  • Mak JW, Singh M, Yap EH, Ho BC, Kang KL (1979) Studies on human filariasis in Malaysia: immunoglobulin and complement levels in persons infected withBrugia malayi andWuchereria bancrofti. Trans Roy Soc Trop Med Hyg 73: 395–399

    Google Scholar 

  • Mak JW, Zaman V (1980) Drug trials with levamisole hydrochloride and diethylcarbamazine citrate in Bancroftian and Malayan filariasis. Trans Roy Soc Trop Med Hyg 74: 285–291

    Google Scholar 

  • Santos LGD, Santos DS, Azevedo R (1976) Diagnosis ofWuchereria bancrofti filariasis by immunofluorescence using microfilariae as antigen. Ann Trop Med Parasitol 70: 219–225

    Google Scholar 

  • Sim BKL, Kwa BH, Mak JW (1982) Immune responses in humanBrugia malayi infections: serum dependent cell-mediated destruction of infective larvaein vitro. Trans Roy Soc Trop Med Hyg 76: 362–370

    Google Scholar 

  • Singh M, Kane GJ, Burren C, Mackinlay LM (1980) Immunofluorescent studies in filariasis: antibody levels in jirds (Meriones unguiculatus) infected withBrugia malayi. J Helminthol 54: 147–153

    Google Scholar 

  • Snedecor GW, Cochran WG (1967) Statistical methods. Sixth edition. Iowa State University Press Ames Iowa USA

    Google Scholar 

  • Tay CH, Yap EH, Singh M, Simons MJ (1975) Serum IgE levels in normal subjects and allergy patients among the chinese in Singapore. Ann Allergy 35: 312–322

    Google Scholar 

  • Wong MM, Guest MF (1969) Filarial antibodies and eosinophilia in human subjects in an endemic area. Trans Roy Soc Trop Med Hyg 63: 796–800

    Google Scholar 

  • Yong WK (1973) Indirect fluorescent antibody technique with microfragments ofWuchereria brancrofti. Trans Roy Soc Trop Med Hyg 67: 338–344

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Filariasis Research Division, Institute for Medical Research, Kuala Lumpur, Malaysia

    Betty K. L. Sim & J. W. Mak

  2. Department of Zoology, University of Malaya, Kuala Lumpur, Malaysia

    B. H. Kwa

Authors
  1. Betty K. L. Sim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. W. Mak
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. H. Kwa
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sim, B.K.L., Mak, J.W. & Kwa, B.H. Immunoglobulin levels in various clinical groups of human Brugian filariasis in Malaysia. Z. Parasitenkd. 69, 371–375 (1983). https://doi.org/10.1007/BF00927878

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00927878

Keywords

Search

Navigation