Abstract
Albino rats and white mice were infected with populations ofTrypanosoma brucei gambiense isolated from patients in four different areas in Central Africa. Differences in virulence as shown by the level of parasitaemia, number of relapses, and length of survival time, were observed amongst the stocks according to their geographical origin and secondarily to the degree of adaptation to the rodents. All the stocks are pathogenic for the laboratory rodents, and the presence of extravascular trypanosomes in the brain was confirmed in all infected animals. Spleen, liver, and kidneys were less constantly found to be positive. The morphology of the extravascular parasites was highly variable, ranging from long slender trypomastigotes to spheromastigotes and even amastigotes.
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References
Frézil JL (1973) Isolement de souches deTrypanosoma brucei gambiense en République Populaire du Congo. Conséquences pratiques et considérations épidémologiques. Cahiers de l'ORSTOM, Ser Ent Med Parasitol XI 3: 195–198
Jennings FW, Whitelaw DD, Holmes PH, Chizyuka HGB, Urquhart GM (1979) The brain as a source of relapsingTrypanosoma brucei infection in mice after chemotherapy. Int J Parasitol 9: 381–384
Larivière M (1957) Etude de l'infection expérimentale àT. gambiense duCricetomys gambianus. Note préliminaire. Bull Med Afr Occid Francaise 2: 122–125
Mehlitz D (1978) Untersuchungen zur Empfänglichkeit vonMastomys natalensis fürTrypanosoma (Trypanozoon) brucei gambiense. Tropenmed Parasitol 29: 101–107
Ormerod WE, Ventakesan S (1971a) The occult visceral phase of mammalian trypanosomes with special reference to the life cycle ofTrypanosoma (Trypanozoon) brucei. Trans R Soc Trop Med Hyg 65: 722–735
Ormerod WE, Ventakesan S (1971b) An amastigote phase of the sleeping sickness trypanosome. Trans R Soc Trop Med Hyg 65: 736–741
Seed JR, Negus NC (1970) Susceptibility ofMicrotus montanus to infection byTrypanosoma gambiense. Lab Anim Sci 20: 657–661
Van Marck EAE, Gigase PLJ, Beckers A, Wéry M (1981) Experimental infections of laboratory rodents with recently isolated stocks ofTrypanosoma brucei gambiense. 2. Histopathological investigations. Z Parasitenkd 64: 187–193
Wéry M (1973) Quatre années d'utilisation de la réaction d'immunofluorescence indirecte pour le diagnostic de la Trypanosomiase au Zaïre. Rapport final de la huitième Conférence technique de l'OCEAC, Yaoundé p 140
Wéry M, Kayembe D (1971) Morphology of the parasites and pathological changes in the brain of albino rats infected withTrypanosoma gambiense. Trans R Soc Trop Med Hyg 65: 409–411
Wéry M, Wéry-Paskoff S, Van Wettere P (1970) The diagnosis of human african trypanosomiasis (T. gambiense) by the use of fluorescent antibody test. 1. Standardization of an easy technique to be used in mass surveys. Ann Soc Belge Med Trop 50: 613–634
Wéry M, Weyn J, Ngimbi NM, Colaert J (1977) Isolement de souches deT. gambiense au Zaïre et leur adaptation aux animaux de laboratoire. Ann Soc Belg Med Trop 57: 425–437
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Beckers, A., Wéry, M., Van Marck, E. et al. Experimental infections of laboratory rodents with recently isolated stocks ofTrypanosoma brucei gambiense . Z. Parasitenkd. 64, 285–296 (1981). https://doi.org/10.1007/BF00927376
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DOI: https://doi.org/10.1007/BF00927376