Zeitschrift für Parasitenkunde

, Volume 64, Issue 1, pp 85–93 | Cite as

Humoral suppression inTrypanosoma cruzi infection in relation to the timing of antigen presentation

  • A. C. Corsini
  • Odete L. P. Oliveira
  • M. G. Costa
Original Investigations


(CBA×C57 B1/10)F1 mice infected intraperitoneally with 100 parasites ofTrypanosoma cruzi strain Y developed an infection with acute and chronic phases. Humoral suppression to sheep red blood cells was evident in both phases but enhancement of the response was achieved only at the beginning of the infection. A mitogen secreted by the parasite could explain both phenomenons.

Key words

Trypanosoma cruzi Immunosuppression Immunenhancement Mice 


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  1. Askonas BA, Corsini AC, Clayton CE, Ogilvie BM (1979) Functional depletion of T and B memory cells and other lymphoid cell subpopulations during trypanosomiasis. Immunology 36:313–321Google Scholar
  2. Assoku RKG, Tizard IR (1978) Mitogenicity of autolysates ofTrypanosoma congolense. Experientia 34:127–129Google Scholar
  3. Barreto AC, Marsden PD, Cuba CC, Alvarenga NJ (1978) Estudo preliminar sobre o emprego doDipetalogaster maximus (Uhler 1894) (Triatominae)na técnica do xenodiagnóstico em forma crônica da Doença de Chagas. Rev Inst Med Trop São Paulo20:183–189Google Scholar
  4. Brener Z (1968) Terapeutica experimental da doença de Chagas. In: Cançado R (ed) Doença de Chagas. Imprensa Oficial do Estado de Minas Gerais, Belo Horizonte, pp 501–516Google Scholar
  5. Clinton BA, Ortiz-Ortiz L, Garcia W, Martinez T, Capin R (1975)Trypanosoma cruzi: Early immune responses in infected mice. Exp Parasitol 37:417–425Google Scholar
  6. Corsini AC, Clayton CE, Askonas BA, Ogilvie BM (1977) Suppressor cells and loss of B cell potential in mice infected withTrypanosoma brucei. Clin Exp Immunol 29:122–131Google Scholar
  7. Corsini AC, Oliveira LP, Costa MG (1980 a) Unimpaired delayed type hypersensitivity in mice infected withTrypanosoma cruzi strain Y. Z Parasitenkd 61:179–185Google Scholar
  8. Corsini AC, Costa MG, Oliveira OLP, Camargo IJB, Stelini Jr A (1980 b) Susceptibility of inbred mice toTrypanosoma cruzi strain Y. Rev Inst Med Trop São Paulo 22:192–196Google Scholar
  9. Coutinho A, Möller G (1975) Thymus independent B cell induction and paralysis. Adv Immunol 21:113–236Google Scholar
  10. Diamanstein T, Keppler W, Blitstein-Willinger E (1976) Suppression of the primary immune response in vivo to sheep red blood cells by B cell mitogens. Immunology 30:401–407Google Scholar
  11. Dresser DW (1978) Assays for immunoglobulin-secreting cells. In: Weir DM (ed) Handbook of experimental immunology. Blackwell Scientific Publications, Oxford, pp 28.1–28.25.Google Scholar
  12. Eardley DD, Jayawardena AN (1977) Suppressor cells in mice infected withTrypanosoma brucei. J Immunol 119:1029–1033Google Scholar
  13. Esuroso GO (1976) The demonstration in vitro of the mitogenic effects of trypanosomal antigen on the spleen cells of normal, athymic and cyclophosphamide treated mice. Clin Exp Immunol 23:314–317Google Scholar
  14. Greenwood BN (1974) Immunosuppression in malaria and trypanosomiasis. In: Porter R, Knight J (eds) Parasites in the immunized host: mechanisms of survival. Ciba Foundation Symposium 25 (New Series). Associated Scientific Publishers, Amsterdam, pp 137–146Google Scholar
  15. Hudson KM, Byner C, Freeman J, Terry RJ (1976) Immunodepression, high IgM levels and evasion of the immune response in murine trypanosomiasis. Nature 264:256–258Google Scholar
  16. Jayawardena AN, Waksman BH, Eardley DD (1978) Activation of distinct helper and suppressor T cells in experimental trypanosomiasis. J Immunol 121:622–628Google Scholar
  17. Lima Pereira FE (1978) Observações sobre a imunodepressão durante a fase aguda da infecção do camundongo Albino peloTrypanosoma cruzi. Ph. D. Thesis. University Federal of Minas GeraisGoogle Scholar
  18. Mansfield JM, Craig SA, Stelzer GT (1976) Lymphocyte function in experimental African trypanosomiasis: mitogenic effects of trypanosome extracts in vitro.Infect Immun 14:976–981Google Scholar
  19. Pizzi T, Agostin M, Christen R, Hoecker G, Neghme A (1949) Estudios sobre imunobiologia de las enfermidades parasitarias. I. Influencia de la constitucion genetica de las lanches a la infection experimental porT. cruzi. Bol Inform Parasit Chil 4:48–49Google Scholar
  20. Ramos C, Lamoyi E, Feoli M, Rodriguez M, Perez M, Ortiz-Ortiz L (1978)Trypanosoma cruzi: Immunosuppressed responses to different antigens in the infected mouse. Exp Parasitol 45:190–199Google Scholar
  21. Ramos C, Schädtler-Siwon I, Ortiz-Ortiz L (1979) Suppressor cells present in the spleens ofTrypanosoma cruzi infected mice. J Immunol 122:1243–1247Google Scholar
  22. Reed SC, Larson CL, Speer CA (1977) Suppression of cell-mediated immunity in experimental Chagas' disease.Z Parasitenkd 52:11–17Google Scholar
  23. Trischman T, Tonowitz H, Wittner M, Bloom B (1978)Trypanosoma cruzi: Role of the immune response in the natural resistance of inbred strains of mice. Exp Parasitol 45:160–168Google Scholar

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • A. C. Corsini
    • 1
  • Odete L. P. Oliveira
    • 1
  • M. G. Costa
    • 1
  1. 1.Department of Microbiology and ImmunologyUniversity of Campinas-UNICAMPCampinasBrazil

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